南京地区近年耐药结核病情况分析  

Analysis of drug resistance trend of Mycobacterium tuberculosis in Nanjing region

作　　者：王生伟[1] 施旭东[2] 王相栋[2] 

机构地区：[1]南京市胸科医院急诊科,江苏南京210029 [2]南京市胸科医院检验科,江苏南京210029

出　　处：《临床肺科杂志》2016年第1期13-16,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的通过统计分析我院检验科近十余年来结核菌培养的药敏试验结果,了解本地区结核菌耐药的现状和变化趋势。方法 2002年1月～2014年12月间,经改良罗氏培养阳性的标本共计12515份,采用SPSS17.0软件对药物敏感试验结果进行整理、归纳和统计学分析。结果大多数常用药物的年耐药发生率在一定范围内波动,异烟肼耐药有下降趋势,耐多药的发生率在下降,而左氧氟沙星耐药率在明显上升,从最初10.93%上升至至24.36%,而且单耐左氧氟沙星的病例数也在增多。结论随着国家对结核病管理的加强和规范,结核病的耐药情况有所改善,但仍应加强对抗结核药物使用的管理,减少耐药的发生。Objective To understand the status and trends of drug-resistant TB in Nanjing region through statistical analysis of susceptibility test results in our hospital laboratory. Methods From January 2014 to December2002,the positive samples of the modified Roche culture were 12515. It used SPSS17. 0 software to analyze the results of drug sensitivity test. Results The incidence of resistance to the most commonly used drugs fluctuated within a certain range. The resistance to isoniazid had downward trend,and levofloxacin showed increasing trend,from 10.93% up to 24. 36%. The incidence of levofloxacin-resistant cases increased significantly. Conclusion Along with the strengthening of TB management,drug-resistant tuberculosis has improved the situation,but it should strengthen the use and management of anti-TB drugs,which can reduce the incidence of drug resistance.

关 键 词：南京地区 耐药结核病 分析 

分 类 号：R521[医药卫生—内科学]