抗结核固定剂量复合剂不同方案治疗新发肺结核转归对比分析  

Comparative analysis of outcomes on different treatment programs with anti tuberculosis fixed-dose combination drug in initial tuberculosis

作　　者：张进国 张保宗 张雁[3] 王凤敏 张绍英 蒋英 梁晓雨 于健 赵敏捷 唐术玲 

机构地区：[1]易县疾病预防控制中心,河北074299 [2]石家庄人民医学高等专科学校 [3]保定市疾病预防控制中心 [4]易县妇幼保健院 [5]易县医院

出　　处：《医学动物防制》2015年第11期1184-1186,1191,共4页Journal of Medical Pest Control

基　　金："十二五"国家科技重大专项(2010ZX09102-301)

摘　　要：目的对不同方案抗结核固定剂量复合剂治疗新发肺结核的转归进行临床对比观察,为抗结核固定剂量复合剂的合理应用提供科学依据。方法将所观察的新发肺结核患者分为每日用药组(每日组)和隔日用药组(隔日组),每日组治疗方案为2HRZE/4HR,隔日组治疗方案为2H3R3Z3E3/4H3R3。对两组治疗转归情况进行对照观察。结果新发涂阳肺结核患者在治疗完成率、停药率、丢失率方面,每日组与隔日组比较差异无统计学意义(χ2=1.12、0.00、0.73,P>0.05);新发涂阴肺结核患者在治疗完成率、停药率、丢失率方面,每日组与隔日组比较差异无统计学意义(χ2=0.29、0.43、0.44,P>0.05);方案变更率每日组小于隔日组,差异有统计学意义(χ2=5.99,P<0.05);断药率每日组与隔日组比较,差异无统计学意义(χ2=1.56,P>0.05)。结论抗结核固定剂量复合剂每日服药和隔日服药在结核病治疗转归方面总体差异无统计学意义。由于抗结核药不良反应容易影响患者服药的依从性,因此临床工作中无论采用哪种服药方案,都应加强患者的治疗管理。Objective To get the comparative observation on outcomes of different treatment programs of anti tuberculosis fixed dose combination drug with initial tuberculosis treatment,providing a scientific basis for the anti tuberculosis fixed- dose combination drug reasonable application. Methods Patients with initial treatment tuberculosis were divided into daily treatment group and the alternate day treatment group,the daily treatment group proposal was 2HRZE /4HR,the alternate day treatment group proposal was 2H3R3Z3E3 /4H3R3. Observe the two groups treatment outcome with the control study method. Results For the tuberculosis patients of initial treatment smear- positive and initial treatment sputum smear- negative,complete treatment rate,loss rate,stop taking the medication rate,there was no significant difference between daily treatment group and the alternate day treatment group（ χ2= 1. 12,0. 00,0. 73,P 〉0. 05; χ2= 0. 29,0. 43,0. 44,P 〉0. 05）.Program change rate of anti tuberculosis daily treatment group was less than that of the alternate day treatment group,the difference was statistically significant（ χ2= 5. 99, P 〈0. 05）. Medication Interruption rate,there was no significant difference between daily treatment group and the alternate day treatment group（ χ2=1. 56,P 〉0. 05）. Conclusions For the treatment outcome of daily treatment way and the alternate day treatment way,there was no significant difference between two groups. However,due to anti tuberculosis drugs adverse reactions was easy affect patients medication compliance,so no matter which treatment programs to choose,should strengthen the management for patients.

关 键 词：肺结核 固定剂量复合剂 每日服药 隔日服药 转归 

分 类 号：R978.3[医药卫生—药品]