全能干细胞在肝脏方向分化研究的进展  

Hepatic differentiation of pluripotent stem cells

作　　者：吉斐 胡安斌[1] 

机构地区：[1]中山大学附属第一医院器官移植中心,广东省广州市510080

出　　处：《世界华人消化杂志》2015年第32期5101-5106,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81371693;81172831;广州市产学研协同创新重大专项民生科技项目;No.2060404;广东省科技计划基金资助项目;Nos.2013B010404016;2012B031800257;广东省自然科学基金资助项目;No.S2013010015935~~

摘　　要：全能干细胞主要包括胚胎干细胞(embryonicstem cell,ESC)和自体诱导多能干细胞(induced pluripotent stem cell,iPSC)两类,其在肝脏方向的分化及移植应用,可为肝细胞替代治疗提供新的细胞来源,有望成为终末期肝病的有效辅助疗法.近年干细胞技术在肝脏领域研究进展迅速,如iPSC可在保留全能分化性的同时大大减轻ESC应用面临的伦理及免疫排斥问题,同时干细胞分化水平也逐渐从肝系细胞的单细胞状态提升到肝脏组织的高度.这些进展一方面推动了肝功能替代治疗技术进步;另一方面也促进了肝脏器官体外发育基础理论的丰富和更新.Pluripotent stem cell mainly contain two types：embryonic stem cell（ESC） and induced pluripotent stem cell（iPSC）.Their hepatic differentiation and application in transplantation may make them serve as new seed cells for replacement therapy and become an effective adjunctive therapy for end-stage hepatic diseases.Recently,great progress has been made in the research of stem cell technology.For example,iPSCs can maintain pluripotency,and the application of iPSCs can avoid the ethical issues associated with the use of ESCs.The research of differentiation of stem cells has greatly shifted from differentiation into hepatic singlecell lineage to differentiation into liver tissues.All of these can improve the development of replacement therapy,and update the basic knowledge of ectogenesis of the liver.

关 键 词：胚胎干细胞 自体诱导多能干细胞 肝脏 分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]