非甾体类抗炎药相关性小肠损伤研究进展  

Advances in research of nonsteroidal anti-inflammatory drugs induced small intestinal injury

作　　者：刘晨晨[1] 樊叶[1] 张振玉[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)消化科,江苏省南京市210006

出　　处：《世界华人消化杂志》2015年第32期5184-5189,共6页World Chinese Journal of Digestology

基　　金：南京市医学科技发展基金资助项目;No.YKK13103~~

摘　　要：非甾体类抗炎药(non-ste roidal antiinflammatory drugs,NSAIDs)具有良好的解热、镇痛、抗炎、抗血小板疗效而广泛应用于临床,但NSAIDs有一定的消化系毒性,尤其会引起NSAIDs相关性小肠损伤.NSAIDs相关性小肠损伤发病率高、临床后果严重,是一个多因素导致的过程.近来,研究显示环氧合酶、肠道菌群、炎症细胞、NSAIDs的肝肠循环、胆汁及线粒体损伤均参与了NSAIDs相关性小肠损伤的发病.本文就NSAIDs相关性小肠损伤的机制及防治等进展作一综述.Non-steroidal anti-inflammatory drugs（NSAIDs） have anti-inflammatory,antipyretic and analgesic properties and have been widely used in clinical practice;however,they can cause cytotoxicity in the gastrointestinal tract,especially in the intestine.The injurious effects of NSAIDs on the small intestine occur frequently and can lead to severe clinical outcomes.A multifactorial etiology is involved in the pathogenesis of these lesions.Current studies found that,in addition to the suppression of cyclooxygenase activity,several factors including enterobacterial invasion,neutrophil migration,enterohepatic cycling of NSAIDs,bile and mitochondrial injury have been implicated in the pathogenesis of these lesions.This article reviews the mechanisms and therapeutic strategies in NSAIDs induced intestinal injury.

关 键 词：非甾体类抗炎药 小肠损伤 环氧合酶 肠道菌群 

分 类 号：R595.3[医药卫生—内科学]