血清胰岛素与C肽释放试验在2型糖尿病患者注射胰岛素后的变化及临床意义  

Serum insulin and C peptide release test in patients with type 2 diabetes mellitus in injection insulin and its clinical significance

作　　者：罗荔[1] 张丽[1] 李小岚[1] 

机构地区：[1]新疆医科大学附属医院内分泌科,新疆乌鲁木齐830011

出　　处：《临床和实验医学杂志》2015年第24期2024-2026,共3页Journal of Clinical and Experimental Medicine

基　　金：新疆维吾尔自治区自然科学基金面上项目(编号2014211C129)

摘　　要：目的根据2型糖尿病患者注射胰岛素后血清胰岛素(INS)与C肽(CP)释放试验的数值,对胰岛β细胞功能进行研究。方法将374例2型糖尿病患者按照血糖水平由低至高分为Ⅰ组、Ⅱ组、Ⅲ组,其中Ⅰ组186例;Ⅱ组133例;Ⅲ组55例;并选取81例健康人群作为对照组。采用化学发光免疫分析法和放射免疫分析法对INS和CP进行检测,并对各组血糖水平、INS、CP结果进行分析,了解2型糖尿病患者胰岛β细胞功能。结果Ⅰ组、Ⅱ组、Ⅲ组0.5 h、1 h、2 h、3 h FPG水平显著高于对照组,组间差异具有统计学意义(P<0.05);Ⅰ组、Ⅱ组、Ⅲ组与对照组相比,0.5 h、1h、2 h INS、CP水平均明显降低(P<0.05);Ⅰ组、Ⅱ组3 h INS、CP水平与对照组相比显著升高(P<0.05),而Ⅱ组3 h INS、CP水平则与对照组无统计学差异(P>0.05)。结论Ⅱ型糖尿病患者胰岛β细胞功能随FPG升高而降低,依据糖尿病人胰岛素、C肽释放试验的数值和糖耐量数值,可以判断胰岛β细胞功能受损程度。Objective According to the numerical test release,the serum insulin and C peptide in type 2 diabetic patients with insulin after injection administration were recorded and studied for the function of islet beta cells. Methods 374 cases with the type 2 diabetes patients were treated in our hospital. According to the blood glucose level,all these patients was divided into groupⅠ,groupⅡ,groupⅢ. At the same time,we selected 81 healthy people as control group. The chemiluminescence immunoassay and radioimmunoassay was used to detect the level of INS and CP,and the blood glucose level,INS,CP results for analysis. All these indexes was used to know of beta cell function in type 2 diabetic patients. Results GroupⅠ,groupⅡ,groupⅢ at 0. 5 h,1 h,2 h,3 h,FPG levels were significantly higher than those in the control group,the difference between groups was statistically significant（ P 〈 0. 05）. Compared with group I,group II,III group and the control group,0. 5 h,1h,2 h,INS,CP levels were significantly decreased（ P 〈 0. 05）. Group Ⅰ,group Ⅱ 3 h,INS,CP levels increased significantly compared with control group（ P 〈 0. 05）,and group II. 3 h INS,CP levels and the control group showed no significant difference（ P 〉 0. 05）. Conclusion Beta cell function in type II diabetes islet decreases with the increase of FPG. According to the numerical and sugar diabetes insulin,C peptide release test of tolerance values can judge the degree of impaired beta- cell function.

关 键 词：2型糖尿病 胰岛素 C肽释放试验 空腹血糖 

分 类 号：R587.1[医药卫生—内分泌]