美洛昔康联合阿仑膦酸钠对膝骨性关节炎合并骨质疏松的临床研究  

Clinical effect of meloxicam combined with alendronate in the treatment of knee osteoarthritis with osteoporosis

作　　者：王玮琪[1] 茹选良[1] 刘春[1] 

机构地区：[1]浙江医院骨科,杭州310013

出　　处：《中国临床药理学杂志》2015年第23期2297-2299,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省医药卫生科技计划基金资助项目(2015KYB001)

摘　　要：目的探讨美洛昔康联合阿仑膦酸钠对膝骨性关节炎合并骨质疏松患者的临床疗效。方法 64例Kellgren-Lawrence 2-3级的膝骨性关节炎合并骨质疏松患者随机分为试验组32例和对照组32例。试验组口服美洛昔康片,每次15 mg,每天3次,连用3个月;口服阿仑膦酸钠片,每次70 mg,每3天1次,连用1个月。对照组仅口服美洛昔康片。比较2组患者的临床疗效、疼痛、僵硬程度、日常活动难度及生存质量。结果治疗后,试验组有效率(96.9%)显著高于对照组(78.1%,P<0.05)。试验组疼痛程度较治疗前显著降低(P<0.05)。试验组的僵硬程度、日常活动难度及生存质量变化情况均显著优于对照组(P<0.05)。结论美洛昔康联合阿仑膦酸钠治疗膝骨性关节炎合并骨质疏松,不仅明显减轻患者疼痛、改善关节僵硬情况,而且可以提高患者生存质量。Objective To explore the clinical effect of meloxicam and alendronate in the treatment of knee osteoarthritis with osteoporosis.Methods A total of 64 cases of Kellgren- Lawrence grade 2- 3 of knee osteoarthritis with osteoporosis patients were randomly divided into treatment group and control group. Treatment group was treated with meloxicam 15 mg,three times a day for three months,and alemdronate 70 mg,once three day for one month. Control group was treated with meloxicam only. The clinical effect,pain,stiff degree,daily activities difficulty and quality of life of the two groups were compared. Results After treatment,total effective rate of treatment group was 96. 9%,significantly higher than 78. 1% in control group（ P〈0. 05）. The pain degree in treatment group after treatment significantly decreased than that before treatment（ P〈0. 05）. The degree of stiffness,difficulty of daily activities and the changes in quality of life were significantly better than those of control group（ P〈0. 05）. Conclusion Meloxicam combined with alendronate in the treatment of knee osteoarthritis with osteoporosis can not only significantly reduce the pain,improve the stiff degree,but also improve the quality of life in early treatment of knee osteoarthritis.

关 键 词：非甾体类止痛药 双膦酸盐类药物 膝骨性关节炎 疼痛 

分 类 号：R684.3[医药卫生—骨科学] R971.1[医药卫生—外科学]