烟酸抑制骨桥蛋白表达及其对骨性关节炎的治疗作用  

Nicotinic acid＇ s inhibition effect on the expression of osteopontin and its therapeutic action on osteoarthritis

作　　者：郭乐运[1] 程伟[1] 余化龙[1] 何宁[1] 刘志刚[1] 熊敏[1] 

机构地区：[1]湖北医药学院附属东风医院骨科研究所,十堰442008

出　　处：《中华实验外科杂志》2015年第12期3116-3117,共2页Chinese Journal of Experimental Surgery

基　　金：十堰市科技局指导项目（14y44）

摘　　要：目的探讨烟酸抑制骨桥蛋白表达及其对骨性关节炎的治疗作用。方法将36只新西兰白兔随机分为实验组、对照组，制备膝关节骨性关节炎模型，于实验第1天实验组加用烟酸每天200mg／kg。8周后制备标本并检测关节滑液中骨桥蛋白（OPN）的含量及软骨下骨OPN的含量，并与关节滑膜组织病理切片进行比较。结果关节滑液中OPN的含量：烟酸组（508．8±110．5）ng／L、对照组（912．4±200．3）ng／L；软骨下骨OPN的含量：烟酸组（2015．97±386．21）ng／L、对照组（3869．82±520．33）ng／L，差异有统计学意义（P〈0．05）。骨性关节炎严重程度与OPN指标的相关性分析，Spearman的相关系数P=0．417，P〈0．01。提示骨性关节炎的严重程度与OPN指标呈正相关。结论烟酸具有抑制骨性关节炎进展的作用。Objective Discussion of nicotinic acid＇ s inhibition effect on the expression of os- teopontin and its therapeutic action on osteoarthritis. Methods Take 36 new Zealand white rabbits and randomly divide them into experimental group and control group, prepare knee osteoarthritis module, add nicotinic acid to the experimental group at the first day of experiment by 200 mg/kg per day. After eight weeks, prepare specimen and detect the osteopontin （OPN） content in synovial fluid and subchondral bone and compare that with pathological section of synovium of joint histamine. Results The OPN content in synovial fluid： nicotinic acid group （508.8 -± 110. 5） ng/L, control group （912. 4 ±200. 3） ng/L; OPN content in subchondral bone： nicotinic acid group （2 015.97 ±386. 21 ） ng/L, control group （3 869. 82 ± 520. 33 ） ng/L, differences are statistically signifieant （ P 〈 0. 05 ）. The correlation analysis of severity of osteoarthritis and OPN index, the correlation coefficient of Spearmanp = 0. 417, P 〈 0. 01. Point out that the severity of osteoarthritis has positive correlation with OPN index. Conclusion Nicotinie acid has effeet of inhibiting the development of osteoarthritis.

关 键 词：烟酸 骨桥蛋白 骨性关节炎 兔 

分 类 号：R684.3[医药卫生—骨科学]