原发性干燥综合征干眼的中西医结合治疗临床研究  

Traditional Chinese medicine and Western medicine treatment of dry eye in primary Sjogren's syndrome

作　　者：文中华[1] 李淑琳[2] 张玉明[1] 杨敏[3] 

机构地区：[1]桂林医学院附属医院眼科,广西 桂林 541001 [2]广西中医药大学附属瑞康医院眼科,广西 南宁 530011 [3]桂林医学院附属医院风湿免疫科,广西 桂林 541001

出　　处：《眼科新进展》2015年第12期1166-1169,共4页Recent Advances in Ophthalmology

基　　金：广西卫生厅科研项目资助(编号:Z2010307);桂林市科技计划项目资助(编号:20140120-1-6)

摘　　要：目的观察中西医综合疗法治疗原发性干燥综合征干眼的临床效果。方法采用前瞻性病例对照研究。纳入患者110例220眼,治疗组及对照组各55例110眼。对照组给予羟糖甘滴眼液、重组牛碱性成纤维细胞生长因子眼用凝胶、睑板腺按摩治疗。治疗组与对照组相同用药及睑板腺按摩治疗的同时,内服润目丰液汤治疗。统计每例患者双眼的每项评价指标数值-干眼症状评分、泪膜破裂时间、SchirmerⅠ试验(无表面麻醉下)、角膜荧光素染色评分,并对数据进行统计学分析。结果治疗组与对照组治疗前干眼症状评分、泪膜破裂时间、SchirmerⅠ试验、角膜荧光素染色评分差异均无统计学意义(均为P>0.05);两组治疗后1周、4周、8周上述各指标随治疗时间的延长较治疗前均有好转,除对照组治疗后1周干眼症状评分与治疗前差异无统计学意义(P>0.05)外,其他时间点各指标与治疗前差异均有统计学意义(均为P<0.05),治疗后相同时间点治疗组上述各指标均优于对照组(均为P<0.05)。结论中西医综合治疗能标本兼顾,更好地改善原发性干燥综合征干眼的临床症状,治疗效果明显。Objective To observe the therapeutic effects of Traditional Chinese medicine（TCM） combined with Western medicine in the treatment of dry eye in primary Sjogren＇s syndrome.Methods A Case-control study was employed.110 patients（220 eyes） were averagely divided into two groups,55 cases（110 eyes） in each group.The control group were treated with Hypromellose 2910,Dextran 70 and Glycerol eye drops,recombinant bovine basic fibroblast growth factor eye gel,tarsal massage therapy.The treatment group received the same treatment as the control group,additionally drunk traditional Chinese medicine Runmufengye soup.The dry eye symptom scores,tear film break-up time,Schirmer I test under no topical anesthesia and corneal fluorescein staining were observed and analyzed.Results There was no statistically significant difference in dry eye symptoms score,tear film break-up time,Schirmer I test,corneal fluorescein staining score between the treatment group and control group before treatment（all P〉0.05）.After treatment of 1 weeks,4 weeks,8 weeks,each index improved over time in the two groups,and there were statistical differences compared with pre-treatment except for 1 week of the control group（all P〈0.05）.The therapeutic effects of the treatment group were better than those of the control group（all P〈0.05）.Conclusion The effect of integrated traditional Chinese medicine and Western medicine treatment can concordance between the outside and the inside.It was obviously better than that of the Western medicine treatment in improving symptoms and clinical signs of dry eye in primary Sjogren＇ s syndrome.

关 键 词：原发性干燥综合征干眼 中西医结合综合疗法 润目丰液汤 

分 类 号：R692.05[医药卫生—泌尿科学]