原纤维蛋白3基因微卫星多态性与中国汉族女性多囊卵巢综合征的相关性  

Microsatellite polymorphisms of fibrillin 3 gene and susceptibility of Chinese Han women to polycystic ovarian syndrome

作　　者：滕家良[1] 殷钢[1] 乔迪[1] 王久林[1] 王勇[2] 黄莉[1] 

机构地区：[1]江苏省老年医学研究所,210024 [2]南京大学医学院免疫与生殖实验室

出　　处：《江苏医药》2015年第23期2800-2802,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(30672228);江苏省中医药局科技项目(LZ13224);南京药学会-常州四药医院药学科研基金(2012YX012)

摘　　要：目的探讨原纤维蛋白3(FBN-3)基因微卫星多态性与中国汉族女性多囊卵巢综合征(PCOS)的易感性的关系。方法对272例PCOS患者(A组)和271例健康体检女性(B组)的FBN-3基因多态性位点D19S884进行基因型分析。结果两组的D19S884的等位基因分布有统计学差异(P<0.05);A组患者的A7等位基因频率高于B组(32.7%vs.26.9%)(P<0.05)。结论 FBN-3基因D19S884位点与中国汉族女性PCOS发病有关,A7等位基因可能是中国汉族女性PCOS的致病因素之一。Objective To investigate the association of microsatellite polymorphisms of fibrillin 3（FBN‐3） gene and susceptibility of Chinese Han women to polycystic ovarian syndrome（PCOS） . Methods The genotype of gene polymorphism loci D19S884 in FBN‐3 gene was analyzed in 272 women with PCOS（group A） and 271 healthy women（group B） .Results The allele distribution of D19S884 in group A was significantly different from that in group B（P〈0 .05） .The frequency of the A7 allele gene was much higher in group A than that in group B（32.7% vs .26.9% ）（P〈0 .05） . Conclusion The gene polymorphism loci D19S884 of FBN‐3 gene is associated with the occurrence of PCOS in Chinese Han women .The A7 allele gene may be related to an increase of the susceptibility to PCOS in Chinese Han women .

关 键 词：原纤维蛋白 多囊卵巢综合征 基因多态性 

分 类 号：R711[医药卫生—妇产科学]