CT灌注成像评估肺癌放化疗疗效的价值  

Value of CT perfusion imaging in evaluating chemoradiation efficacy of lung carcinoma

作　　者：何强[1] 袁刚[2] 

机构地区：[1]南京医科大学附属常州市第二人民医院放射科,江苏省213003 [2]连云港市第一人民医院影像科

出　　处：《江苏医药》2015年第23期2817-2819,共3页Jiangsu Medical Journal

摘　　要：目的探讨CT灌注成像在评估肺癌放化疗疗效中的价值。方法肺癌患者33例放化疗前1周及放化疗后1周内行CT灌注成像,测定肿瘤血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面通透性(PS);评估疗效,随访1年肿瘤复发情况。结果与放化疗前比较,有效者(27例)的BF降低[(68.82±39.31)ml·min^(-1)·100g^(-1) vs.(93.60±41.33)ml·min^(-1)·100g^(-1)](P<0.05),MTT延长[(12.44±9.29)s vs.(7.36±4.87)s](P<0.05);而无效者(6例)放化疗前后的BF和MTT均无统计学差异(P>0.05)。有复发转移者(9例)的BF低于无复发转移者(24例)[(53.44±28.08)ml·min^(-1)·100g^(-1) vs.(95.27±44.76)ml·min^(-1)·100g^(-1)](P<0.05)。结论 CT灌注成像可为肺癌个性化肿瘤治疗方案的确定、疗效判定及预后评估提供依据。Objective To explore the role of CT perfusion imaging in evaluating the chemoradiation efficacy of lung carcinoma .Methods Thirty three patients with lung carcinoma underwent CT perfusion examination one week before and one week after chemoradiation therapy . Tumor blood flow （BF） ,blood volume ,mean transit time （MTT ） and permeability surface were measured .The efficacy was evaluated and the recurrence was observed by one year follow‐up .Results Compared to before ,the BF was decreased[（68.82 ± 39.31） ml · min^-1 · 100 g^-1 vs .（93.60 ± 41.33） ml·min^-1·100g^-1]（P〈0.05）,andMTTwasprolonged[（12.44±9.29）svs.（7.36±4.87）s] （P〈0 .05） in 27 cases with effective chemoradiation therapy ,which were not significantly changed in 6 cases without effective chemoradiation therapy .The BF was lower in 9 cases with recurrence than that in 24 cases without recurrence[（53.44 ± 28.08） ml · min^-1 · 100 g^-1 vs .（95.27 ± 44.76） ml · min^-1 · 100 g^-1 ]（P〈0 .05） .Conclusion CT perfusion imaging can provide the basis for individualized treatment ,as well as the evaluation of efficacy and prognosis in the patients with lung carcinoma .

关 键 词：肺癌 CT灌注成像 放化疗 

分 类 号：R445[医药卫生—影像医学与核医学]