天舒滴丸对麻醉犬颅内循环的影响  

Effects of Tian-Shu Dripping Pills on Cerebral Blood Circulation among Anesthetized Canine

作　　者：衡晴晴[1] 唐朝辉[1] 曹亮[1] 李娜[1] 丁岗[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2015年第9期1790-1794,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科技部重大新药创制项目(2012ZX09201201-002):偏头痛治疗药物天舒胶囊大品种技术改造;负责人:萧伟

摘　　要：目的:观察天舒滴丸对麻醉犬颅内血液循环的影响,探讨天舒滴丸治疗血管神经性头痛的机理。方法:杂种家犬25条,随机分为生理盐水组、天舒胶囊组(阳性对照:生药0.4 g·kg-1)、天舒滴丸低剂量组(生药0.2 g·kg-1)、天舒滴丸中剂量组(生药0.4 g·kg-1)、天舒滴丸高剂量组(生药0.8 g·kg-1),麻醉后一次性十二指肠给药,测量并记录平均动脉血压、椎动脉血流量和颈内动脉血流量,并计算脑血流量和脑血管阻力,观察天舒滴丸对犬脑血流量的影响。结果:天舒滴丸低、中、高剂量组均能在给药后180 min内明显降低脑血管阻力,增加脑血流量。结论:天舒滴丸具有改善犬颅内血液循环的作用,其机理可能是通过降低脑血管阻力,增加脑血流量来实现。This study was aimed to observe the effects of Tian-Shu Dripping Pills（TSDP） on cerebral hemodynamics among anesthetized dogs, in order to demonstrate its clinical treatment functional correlation on angioneurotic headache. A total of 25 hybrid dogs were randomly divided into the normal saline（NS） group, TS capsule（positive control： 0.4 g·kg-1 crude medicine） group, low-dose TSDP（0.2 g·kg-1 crude medicine） group, middle-dose TSDP（0.4 g·kg-1 crude medicine） group, and high-dose TSDP（0.8 g·kg-1 crude medicine） group. Intraduodenal administration was given once under anesthesia. Changes of mean arterial blood pressure, blood flow of vertebral artery and internal carotid artery blood flow were detected and the cerebral blood flow and cerebral vascular resistance were calculated. The results showed that TSDP of low-dose, middle-dose and high-dose group can significantly reduce the cerebral vascular resistance and increase the cerebral blood flow within 180 min after medication. It was concluded that TSDP can improve the cerebral blood circulation of anesthetized dogs. Its mechanism may be through the reduction on cerebral vascular resistance and increasing of cerebral blood flow.

关 键 词：天舒滴丸 脑血流量 脑血管阻力 

分 类 号：R277.7[医药卫生—中医学]