光遗传学技术用于调控细胞信号通路的研究  

Studies of Optogenetic Control of Intracellular Signaling Pathways

作　　者：南迪[1,2] 许迎科[1,2] 

机构地区：[1]浙江大学生物医学工程系,杭州310027 [2]生物医学工程教育部重点实验室浙江省心脑血管检测技术与药效评价重点实验室,杭州310027

出　　处：《中国细胞生物学学报》2015年第11期1560-1565,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31301176;31571480);浙江省自然科学基金(批准号:LY13C050001);教育部博士点基金(批准号:20130101120172)资助的课题~~

摘　　要：光遗传学技术结合蛋白的遗传学表达与激光的光控和成像,可实现对细胞内特定信号通路分子的快速激活与调控,在细胞生物学的研究中具有广阔的应用前景。至今为止,越来越多的光控元件被发现,它们具备不同的结构特征及光反应特性,极大的扩展了光遗传学技术的生物医学应用。该综述将对不同种类的光控元件及其应用于活细胞中信号通路调控的研究进行总结。Optogenetics combines genetic expression with optical controlling and imaging, which permits rapidly activation and regulation of the activities of intracellular signaling molecules. Optogenetics has great promise in cell biology applications. To date, a variety of photoactivatable modules have been identified. They have distinct structure and photoactivation features, and those have greatly extended optogenetics in the biomedical research. In this review, we will introduce different species of photoactivatable modules, their distinct photon properties, and with an emphasis on their applications in using light to control intracellular cell signaling.

关 键 词：光遗传学 光敏蛋白 信号转导 

分 类 号：Q25[生物学—细胞生物学]