血清游离脂肪酸在强直性脊柱炎患者中的水平及其临床价值  

The levels and clinical value of serum free fatty acid in patients with ankylosing spondylitis

作　　者：彭友帆 曹文艳 曹玲 张朝霞 孟存仁 陈丹[2] 张琼 

机构地区：[1]靳疆医科大学第一附属医院医学检验中心,乌鲁木齐830011 [2]新疆医科大学第一附属医院医学风湿免疫科,乌鲁木齐830011

出　　处：《中华风湿病学杂志》2015年第12期819-823,共5页Chinese Journal of Rheumatology

基　　金：国家高技术研究发展计划（863计划）（2011AA02A111）

摘　　要：目的探讨血清游离脂肪酸（FFA）与AS患者的关系。方法根据制定的标准，纳入90例初诊AS患者、82例非炎性疾病组以及223名健康对照，采集空腹血行血清生物化学和临床免疫学等检测。采用单因素方差分析比较3组血清学指标的差异，采用Logistic回归分析与As相关的风险因素。结果3组基本资料比较结果显示，性别、年龄、BMI、白细胞、LDL-C、HDL—C、脂蛋白[Lp（a）]、ALP以及TG差异均无统计学意义。血清FFA在3组间差异有统计学意义（F=24．191，P〈0．01），组内结果比较显示，AS患者的血清FFA水平显著高于非炎性疾病组和健康对照人群[（0．48±0．18）mmol／L；（0．28±0．09）mmol／L，（0．29±0．16）mmol／L；t=-5．969，P〈0．01；t=5．106，P〈0．01]。同时，IgA、IgG、IgM、ESR以及CRP3组间差异有统计学意义（F=14．870，P〈0．01；F=16．464，P〈0．01；F=4．124，P=0．018；F=97．002，P〈0．01；F=22．069，P〈0．01）。应用Logistic回归分析结果显示，性别、年龄、BMI、IgA、IgM、ALP、HDL—C、LDL．C、Lp（a）及TG与AS不相关，血清IgG、ESR以及CRP与AS相关[D尺（95％CI）：1．659（1．032，2．660），P=0．037；OR（95％CI）：1．340（1．005，1．787），P=0．046；OR（95％CI）：1．820（1．025，3．232），P=0．041]，并且，血清FFA与AS相关[OR（95％CI）：1．132（1．014，1．421），P=0．033]。结论血清高水平的FFA与AS存在密切联系，血清FFA可能是AS的危险因素。Objective To study the association between serum free fatty acid （FFA） and ankylosing spondylitis （AS）. Methods According to the classification criteria, a total of 90 newly diagnosed AS patients, 223 healthy individuals and 82 patients with non-inflammatory diseases were divided into three groups, and biochemistry and immunology biomarks were measured in all individuals. One-Way analysis of variance （ANOVA） test was used to compare the difference between the three groups in the serum indexes, and Logistic regression analysis was used to identify AS risk factors associated with AS. Results There were no significant differences in gender, age, body mass index （BMI）, white blood cells （WBC）, high-level data link control （HDL-C）, low-density lipoprotein control （LDL-C）, lipoproteins [Lp （a）], alkaline phosphatase （ALP） and TG in the three groups, and our results showed that serum FFA was statistical different between the three groups （F=24.191, P〈0.01）, the serum level of FFA in patients with AS was higher compared with patients with non-inflammatory diseases and healthy controls [（0.48 ±0.18） mmot/L, （0.28 ±0.09） mmol/L, （0.29 ±0.16） mmol/L; t=-5.969, P〈0.01; t=5.106, P〈0.01]. Seral IgA, IgG, IgM levels, ESR and CRP were statistically different between the three groups （F=14.870, P〈0.01; F=16.464, P〈0.01; F=4.124, P=O.018; F=97.002, P〈0.01; F=22.069, P〈0.01）. Gender, age, BMI, serum IgA, IgM, ALP, HDL-C, LDL-C, Lp（a） and TG levels were not associated with AS by logistic regression analysis. However, serum IgG level, ESR and CRP were associated with AS [0R（95%C1）： 1.659（1.032, 2.660）, P=0.037; 0R（95%C1）： 1.340（1.005, 1.787）, P=-0.046; 0R（95%CI）： 1.820 （1.025, 3.232）, P=0.041], and there is an association between FFA and AS was observed in logistic regression analysis （OR=1.132, 95%CI： 1.014-1.421, P=0.033）. Conclusion We suggest that incre-ased FFA is closely associated with AS, and may be an underlying r

关 键 词：脊柱炎 强直性 脂肪酸类 非酯化 C反应蛋白质 红细胞沉降率 

分 类 号：R593.23[医药卫生—内科学]