早期使用依达拉奉注射液预防中重型颅脑损伤患者并发外伤性脑梗死  

The Early Use of Edaravone Injection to Prevent of Cerebral Infarction in Patients with Severe Craniocerebral Injury

作　　者：彭涛[1] 李定君[2] 徐宏[3] 邹兴军[1] 唐渊[1] 张袁汇翼 

机构地区：[1]彭州市人民医院神经外科,四川彭州611930 [2]成都中医学院附属医院神经外科,四川成都610072 [3]德阳市人民医院神经外科,四川德阳618000

出　　处：《四川医学》2015年第11期1512-1514,共3页Sichuan Medical Journal

基　　金：成都市卫生局科研课题(编号:2014023)

摘　　要：目的观察早期使用依达拉奉注射液对中重型颅脑损伤患者并发外伤性脑梗死的预防效果。方法采用前瞻性对比研究,对我院2010年5月至2013年5月期间248例中重型创伤性脑损伤患者,随机分为治疗组120例,采用依达拉奉30mg,2次/d,静脉滴注,连用7d;对照组128例,使用等量生理盐水对比治疗。观察两组患者脑梗死的发生率和3个月后的GOS评价,并行统计学分析。结果治疗组和对照组的外伤性脑梗死发生率分别为:8.3%(10/120)和18.8%(24/128),两者差异有统计学意义(P<0.05)。结论早期应用依达拉奉注射液治疗中重度颅脑损伤,可减少外伤性脑梗死发生数量。Objective To study the therapeutic effect of posttraumatic cerebral infarction on moderate and severe traumatic brain injury patients complicated with edaravone early therapy. Methods 248 patients of moderate and severe traumatic brain injury were analyzed and compared retrospectively,who were randomly allocated into treatment group and comparative group. The treatment group was took 30 mg of edaravone intravenous injection two times a day,in 7 days,and the control group that accepted equivalent normal saline. The incidence of posttraumatic cerebral infarction and curative effect of GOS after 3 months were observed. Results The incidence of traumatic cerebral infarction in the treatment group and the control group were： 8. 3%（ 10 /120） and 18. 8%（ 24 /128）,the difference was statistically significant（ P 〈0. 05）. Conclusion Early application of edaravone injection in the treatment of severe cerebral infarction,can reduce the incidence of traumatic cerebral infarction.

关 键 词：依达拉奉 颅脑损伤 外伤性脑梗死 

分 类 号：R651.15[医药卫生—外科学]