血清降钙素原对扩张性心肌病患者感染的诊断评价  

Evaluation of serum procalcitonin for diagnosis of infections in patients with dilated cardiomyopathy

作　　者：刘慧[1] 李海剑[1] 高传玉[2] 李玉东[1] 陶亚非[1] 毛绍芬[1] 

机构地区：[1]南阳市中心医院心内科,河南南阳473009 [2]河南省人民医院心内科,河南郑州450003

出　　处：《中华医院感染学杂志》2015年第24期5622-5624,共3页Chinese Journal of Nosocomiology

基　　金：河南省杰出人才创新基金资助项目(0621002500)

摘　　要：目的探讨血清降钙素原(PCT)对扩张性心肌病患者感染的诊断价值,以尽快诊断并治疗感染患者,改善患者预后。方法选取2012年1月-2014年12月128例扩张性心肌病中发生感染的67例患者作为感染组,其余未感染61例患者作为对照组,对比两组患者治疗前后血清PCT水平变化和分布、血清PCT对感染的预测价值,数据采用SPSS 19.0软件进行统计分析。结果 128例扩张性心肌病患者经过积极治疗后109例好转出院,19例患者死亡,病死率14.8%,感染组患者的病死率16.4%与对照组患者的病死率13.1%之间差异无统计学意义;治疗前,感染组的血清PCT水平(10.9±3.2)ng/ml显著高于对照组的(0.3±0.2)ng/ml,差异有统计学意义(P<0.01);以PCT>2.0ng/ml作为阳性诊断标准,血清PCT诊断扩张性心肌病患者发生感染的灵敏度为89.6%、特异度为90.2%。结论血清PCT对扩张性心肌病患者感染具有重要的诊断价值。OBJECTIVE To explore the diagnosis effect of serum procalcitonin （PCT） for infections in patients with dilated cardiomyopathy, so as to diagnose and treat infected patients as soon as possible and improve the prognosis of the patients. METHODS; The clinical data of 128 patients with dilated cardiomyopathy from Jan. 2012 to Dec. 2014 were analyzed, including 67 cases complicated with infections as the infection group and the rest 61 patients as the control group. Clinical outcomes were compared between 2 groups before and after treatment, such as the serum procalcitonin level and distribution and the predicting value of serum proealcitonin for infections. The soft- ware SPSS 19.0 was used for statistical analysis. RESULTS Among the 128 cases of dilated cardiomyopathy after active treatment, 109 cases recovered and were discharged, 19 patients died, the mortality was 14.8%. There was no significant difference in mortality between the infection group （16.4 %） and the control group （13.1 % ）. Before treatment, the level of serum procalcitonin was （10.9 ± 3.2） ng/mL in the infection group, significantly higher than （0. 3±0.2） ng/mL in the control group （P〈0.01）, Taking PCT 〉2.0 ng/mL as a diagnostic criterion, the sensitivity of serum procalcitonin in diagnosis of infection in patients with dilated cardiomyopathy was 89. 6% and the specificity was 90.2 %. CONCLUSION Serum PCT has important value in the diagnosis of infections in patients with dilated cardiomyopathy.

关 键 词：降钙素原 扩张性心肌病 感染 诊断价值 

分 类 号：R446[医药卫生—诊断学]