甲状腺过氧化物酶抗体在自身免疫性甲状腺疾病诊治中的价值及存在问题  

The value and controversy of thyroid peroxidase antibody in the diagnosis and treatment of autoimmune thyroid disease

作　　者：范慧[1] 王广[1] 

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,100020

出　　处：《中华检验医学杂志》2015年第12期884-887,共4页Chinese Journal of Laboratory Medicine

摘　　要：甲状腺过氧化物酶抗体（TPOAb）在自身免疫性甲状腺疾病（AITD）的诊断中起着不可替代的作用，化学发光免疫分析（CLIA）是近年来大力推广的检测TPOAb的新方法，目前TPOAb正常参考值和医学决定水平数值的界定不一致，确定TPOAb正常参考区间和医学决定水平以及探讨抗体阳性人群的AITD发生发展的规律具有重要意义。桥本甲状腺炎患者的TPOAb显著升高，且TPOAb的浓度与淋巴细胞的浸润程度和甲状腺滤泡破坏程度相关。TPOAb是监测产后甲状腺炎的重要的检测项目，且应于妊娠早期测定。TPOAb阳性与多种原因所致不良妊娠结局有关。当甲亢合并明显升高的TPOAb时要考虑Graves病合并桥本甲状腺炎。Thyroid peroxidase antibody （TPOAb） play an important role in the diagnosis of autoimmune thyroid disease. Chemiluminescence immunoassay （CLIA） is a new method been strongly recommended in recent years. The definition of positive value of TPOAb is inconsistent. The definition of TPOAb positive value is important for exploring the development of autoimmune thyroid disease. TPOAb is significantly increased in Hashimoto＇s disease and the titer is associated with the degree of infiltration and destruction of thyroid follicular. It is essential to monitor TPOAb in postpartum thyroiditis and early pregnancy. The positive of TPOAb is closely related to the adverse pregnancy outcomes caused by various risk factors. Graves disease combined with Hashimoto＇s must to be considered.

关 键 词：甲状腺疾病 甲状腺炎 自身免疫性 碘化物过氧化物酶 自身抗体 

分 类 号：R581[医药卫生—内分泌] R446.6[医药卫生—内科学]