亚洲人群中SDF1-3’A和CCR2-64I基因的多态性与HIV-1感染相关性的Meta分析  

Association of SDF1-3'A and CCR2-64I gene polymorphisms with HIV-1 infection in Asians: a meta-analysis

作　　者：苏威武 袁泉 贺小峰[3] 刘杨[4] 

机构地区：[1]长沙市岳麓区疾病预防控制中心,湖南长沙410013 [2]长沙市卫生监督所 [3]山西省长治医学院附属和平医院科研科 [4]中南大学湘雅三医院病理科

出　　处：《实用预防医学》2016年第1期35-39,共5页Practical Preventive Medicine

摘　　要：目的探讨SDFl-3’A和CCR2-641基因的多态性与HIv-1感染之间的关联性。 方法检索国内外有关SDFl-3’A和CCR2-64I基因的多态性与HIV感染相关性的病例对照研究文献进行Meta分析。 结果符合CER2-64I入选条件的文献有13篇，20个研究，总共有5 578例样本，其中病例有2 898例，健康对照有2 680例，当CCR2-64I基因所入选的研究全部合并在一起时，在所有模型中没有发现其显著相关性（CY VS．CC：OR=0．97，95％a=0．85-1．09；CY＋YYUS．YY：OR=1．00，95％CI=0．89-1．13；YY＂US．CA2：OR=1．28，95％CI=0．97-1．69）。符合SDFl-3’A入选条件的文献13篇，19个研究，总共有4 854例，其中病例有2 281例，健康对照有2 573例，在整个和亚组分析中没有发现其显著相关性。而在印度人群发现高度的异质性。 结论亚洲人群CCR2-641两种抗性基因与HIV一1感染之间无相关性；中国人群SDFl-3’A与HIV-1感染之间无相关性；印度人群SDFl-3’A与HIV-1感染之间是否有相关性仍需作进一步的研究。Objective To explore the association of SDF1 - 3＇A and CCR2 - 64I gene polymorphisms With susceptibility toHIV- 1 infection in Asians. Methods A meta- analysis was conducted to identify all case- control studies on SDF1 - 3＇ Aand CCR2 - 64I gene polymorphisms by searching domestic and international literatures. Results Thirty articles and 20 stud-ies on CR2 - 64I were found, involving 5,578 subjects （including 2,898 cases and 2,680 healthy controls）. No significant asso-ciation was observed in any genetic modal when all the eligible studie＇s were pooled into meta analysis of CCR2 - 64I （CY vs.CC： 0R=0.97,95%CI=0.85- 1.09; CY ＋ YY vs. YY：OR = 1.00,95%（2/=0.89- 1.13;YY vs. CC：OR = 1.28,95% CI - 0. 97 - 1.69）. 13 articles and 19 studies on SDF1 - 3＇A were found, involving 4,854 subjects （including 2,281 casesand 2,573 healthy controls）. No significant association was found in overall analysis and any subgroup analysis, while high het-erogeneity was found in Indians. Conclusions The meta- analysis suggests that CCR2 - 641 poIymorphism may he not asso-ciated with HIV- 1 - infected risk in Asians, and SDF1 - 3＇ A polymorphism may be not associated with HIV - 1 - infected riskin Chinese population. In addition, our results also indicate the necessity for further studies on association between SDF1 - 3＇ Aand HIV- 1 infection in Indians.

关 键 词：HIV-1感染 CCR2 SDF 基因多态性 

分 类 号：R183.7[医药卫生—流行病学]