肾病Ⅰ、Ⅱ、Ⅲ号方分阶段辨证治疗难治性肾病综合征的研究  

Study on the treatment of refractory nephrotic syndrome by administration of kidney disease Ⅰ,Ⅱ,Ⅲ decoction according to different stages and syndrome differentiation

作　　者：黄仁发[1] 梁群卿[1] 赖虹伊 林心如[2] 向少伟[1] 唐丽萍[1] 龙韵[1] 胡维[1] 谭嘉臻[1] 葛旭[1] 马晓露[1] 

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]广西中医药大学,广西南宁530011

出　　处：《现代中西医结合杂志》2016年第1期4-6,10,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广西中医药管理局中医药科技专项基金资助项目(GZTP13-17)

摘　　要：目的观察肾病Ⅰ、Ⅱ、Ⅲ号方分阶段治疗难治性肾病综合征的临床疗效。方法将76例难治性肾病综合征患者随机分为2组,对照组给予常规西医治疗,治疗组在对照组治疗基础上分阶段予以肾病Ⅰ、Ⅱ、Ⅲ号方治疗。观察2组治疗前后24h尿蛋白定量、血清白蛋白(ALB)、血胆固醇(TC)、三酰甘油(TG)、血尿素氮(BUN)、血肌酐(SCr)、血常规及水肿、乏力、腹胀、腰酸证候积分变化情况,统计2组疾病疗效及疾病缓解的时间、中医证候疗效及感染、肝损害情况。结果治疗后24 h 2组尿蛋白定量、ALB、TC、TG、BUN、SCr均较治疗前明显改善(P均<0.05),且治疗组24 h尿蛋白定量、ALB、TC、TG改善情况均明显优于对照组(P均<0.05);治疗后2组BUN、SCr比较差异无统计学意义。治疗后2组各项中医证候积分均较治疗前明显改善(P均<0.05),且治疗组改善情况明显优于对照组(P均<0.05)。治疗组疾病缓解率和中医证候总有效率均明显高于对照组(P均<0.05),感染和肝损害发生率均明显低于对照组(P均<0.05)。结论肾病Ⅰ、Ⅱ、Ⅲ号方联合常规西医治疗难治性肾病综合征疗效好,且可减少感染及肝损害的发生。Objective It is to observe the clinical effect of kidney disease Ⅰ、Ⅱ、Ⅲ decoction on refractory nephrotic syndrome according to different stages and syndrome differentiation. Methods 76 patients with refractory nephrotic syndrome were divided into control group and treatment group. The patients in the control group were given normal western medicine therapy. The patients in the treatment group were given kidney disease Ⅰ、Ⅱ、Ⅲ decoction according to different stages and syndrome differentiation following the treatments of control group. The changes of 24 b urinary protein, serum ALB, TC, TG, BUN, SCr, blood normal examination and clinical symptom scores before and after treatment were observed in both groups. Results After treatment 24h urinary protein, serum ALB, TC, TG, BUN, SCr and syndrome scores of TCM were all improved significantly compared with that before treatment in both groups（ P 〈 0.05 ） , and the the improvements of 24h urinary protein, serum ALB, TC, TG in treatment group were better than that in control group （ P 〈 0.05 ） , there were no significant difference in BUN and SCr between the two groups after treatment. Both infection rate and live damage occurrence rate in the treatment group were lower while disease relieving rate and total effective rate of TCM syndrome were higher than that in the control group （P 〈 0.05）. Conclusion Kidney Ⅰ、Ⅱ、Ⅲ decoction combined with normal western medicine have good curative effect on refractory nephrotic syndrome, and could reduce the occurrence of infection rate and live damage.

关 键 词：难治性肾病综合征 肾病Ⅰ号方 肾病Ⅱ号方 肾病Ⅲ号方 

分 类 号：R692[医药卫生—泌尿科学]