综合外治疗法治疗COPD缓解期的临床疗效及对肺功能的影响  

Effect of comprehensive external therapy on stable COPD and pulmonary function

作　　者：郭洁[1] 张勇[2] 赵妍[3] 田振峰[4] 魏丽瑛 褚睿[1] 魏树慧[1] 武蕾[1] 

机构地区：[1]河北省中医院,河北石家庄050011 [2]华北油田总医院,河北任丘062550 [3]河北医科大学,河北石家庄050000 [4]河北省石家庄市第一医院,河北石家庄050011

出　　处：《现代中西医结合杂志》2016年第1期21-24,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2012037);河北省中医药管理局科研计划项目(2013052)

摘　　要：目的探讨综合外治疗法对慢性阻塞性肺疾病(COPD)缓解期患者临床症状及对肺功能的影响。方法将60例COPD缓解期患者作为观察对象,随机分为对照组及治疗组,每组30例。对照组给予常规治疗,治疗组给予常规治疗联合综合外治疗法治疗,2组均以60次为1个疗程,分别于治疗前后采用酶联免疫吸附法对2组进行血清IL-6水平和痰液LTB4检测,并比较2组治疗前后肺功能变化。结果治疗后2组血清IL-6水平和痰液LTB4较治疗前均有所降低,且治疗组降低幅度明显大于对照组,治疗后组间比较差异有统计学意义(P<0.05);治疗后2组FEV1、FEV1/FVC均有好转,而治疗组肺功能检测明显优于同期对照组,差异有统计学意义(P均<0.05);治疗后2组患者活动受限、呼吸症状、疾病影响及总分等均低于同期对照组(P均<0.05);临床总有效率治疗组好于对照组(P<0.05);治疗后2组生活质量均较前提高,治疗组生活质量明显优于同期对照组(P<0.05)。结论综合外治疗法可显著提高COPD缓解期的临床治疗效果,能显著降低COPD缓解期患者血清IL-6水平,从而有效控制炎症复发,改善患者肺功能,且综合外治疗法操作方便,患者依从性好。Objective It is to explore the effect of comprehensive external therapy on stable chronic obstructive pulmonary disease （COPD） and pulmonary function. Methods 60 stable COPD patients were randomly divided into 2 groups： treatment group and control group, with 30 cases in each group. The control group was treated with normal therapy, and the treatment group was treated with normal therapy combined with comprehensive external therapy. 60 days were one treatment course in both groups. Serum level of IL - 6 and LTB4 in sputum were measured by ELISA before and after treatment and the changes of lung function were compared in both groups. Results Compared with that before treatment, the level of serum IL - 6 and LTB4 in sputum decreased after treatment in both groups, and the decrease was more significant in treatment group than that in control group （P 〈0.05）. After treatment FEV1 and FEV1/FVC were both improved in both groups, and the indexes of lung function in treatment group were better than that in control group （P 〈 0.05） , the scores such as activity limit, breath symp- toms, disease effect in treatment group were better while the total effective rate was higher than that in control group （P 〈 0.05） , life quality was significantly improved in both groups, and the improvement was better in treatment group than that in control group （ P 〈 0.05 ）. Conclusion Comprehensive external therapy can significantly improve the treatment effect on stable COPD, decrease the serum level of IL - 6, thus to effectively control recurrence of inflammation, improve lung function, with a easy operation and good patient compliance.

关 键 词：综合外治法 慢性阻塞性肺疾病 缓解期 

分 类 号：R563.3[医药卫生—呼吸系统]