苯甲酸阿格列汀的合成  

Synthesis of alogliptin benzoate

作　　者：江洁滢 游莉[1] 邓思思[1] 邓俊丰[1] 刘瑜[1] 张晓[1] 

机构地区：[1]四川抗菌素工业研究所,四川成都610052

出　　处：《化学研究与应用》2015年第12期1867-1869,共3页Chemical Research and Application

摘　　要：本文以邻溴甲苯为原料,经催化偶联,自由基反应,烷基化反应,取代,成盐5步制得二肽基肽酶IV(DPP-IV)抑制剂苯甲酸阿格列汀,所得目标化合物经质谱,核磁共振氢谱确认,总收率达31.5%。Alogliptin benzoate was synthesized from 2-bromotoluene by catalytic coupling reaction, radical reaction, alkylation reaction,substitution reaction and salt-forming The target compound was identified by MS and 1H-NMR, and the overall yield was 31.5%.

关 键 词：二肽基肽酶IV抑制剂 苯甲酸阿格列汀 合成 

分 类 号：O626.41[理学—有机化学]