血浆可溶性髓样细胞触发受体-1在脓毒性休克预后评估中的价值  

Value of plasma soluble triggering receptor expressed on myeloid cells-1 to predicting the prognosis of septic shock

作　　者：陶飞 吴翔 胡桂芳[2] 邓烈华[2] 姚华国[2] 

机构地区：[1]佛山市禅城区中心医院ICU,广东佛山528031 [2]广东医学院附属医院ICU,广东湛江524001

出　　处：《中华实用诊断与治疗杂志》2015年第12期1229-1231,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨血浆可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1,sTREM-1)评估脓毒性休克患者预后的价值。方法 42例脓毒性休克患者均给予集束化治疗,28d后存活33例为生存组,死亡9例为死亡组,检测并比较2组入住ICU第1、3、5天血浆sTREM-1水平,急性生理和慢性健康评分Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)及全身感染相关性器官功能衰竭评分(Sepsis-related Organ Failure Assessment,SOFA),分析sTREM-1水平与APACHEⅡ、SOFA评分的相关性。结果死亡组入住ICU第3、5天血浆sTREM-1水平[(568.49±46.02)、(603.58±28.82)ng/L]、APACHEⅡ评分(34.50±4.46、38.37±4.39)、SOFA评分(14.64±3.97、18.15±3.84)高于生存组[血浆sTREM-1(396.11±27.05)、(172.58±13.32)ng/L,APACHEⅡ评分24.59±5.86、15.46±6.67,SOFA评分10.21±1.85、6.98±2.10](P<0.05);Spearman相关分析结果显示,血浆sTREM-1水平与APACHEⅡ评分(r=0.472,P=0.033)、SOFA评分(r=0.528,P=0.005)呈正相关。结论血浆sTREM-1水平可用于脓毒性休克患者预后的评估。Objective To investigate the clinical value of plasma soluble triggering receptor expressed on myeloid cells 1 （sTREM-1） to predicting the prognosis of septic shock. Methods Forty-two patients with septic shock were divided into survival group （n=33） and dead group （n= 9） alter 28-day bundle treatment. The sTREM-1 levels, Acute Physiology and Chronic Health Evaluation II （APACHE II ） scores and Sepsis-related Organ Failure Assessment （SOFA） scores were detected by day 1, 3 and 5 after admission into ICU and compared between two groups. Results The sTREM-1 levels （（568.49±46.02）, （603.58±28.82） ng/L）, APACHE II scores （34.50±4.46, 38.37±4.39） and SOFA scores （14.64 ± 3. 97, 18. 15±3. 84） by day 3 and 5 in dead group were significantly higher than those in survival group （sTREM-1： （396.11±27.05）, （172. 58±13. 32） ng/L; APACHE II scores： 24. 59±5. 86, 15.46±6. 67± SOFA scores： 10.21±1.85, 6.98±2.10） （P〈0.05）. Spearman analysis showed plasma sTREM-1 was positively correlated with APACHE II score （r=0. 472, P=0. 033） and SOFA score （r=0. 528, P=0. 005）. Conclusion The sTREM-1 level might be considered as a valuable prognostic factor for the patients with septic shock.

关 键 词：脓毒性休克 可溶性髓样细胞触发受体-1 急性生理和慢性健康评分Ⅱ 全身感染相关性器官功能衰竭评分 

分 类 号：R459.7[医药卫生—急诊医学]