利用SBA-15—SO_3H或硅胶硫酸脱除硅醚保护基团方法（英文）  

Efficient Methods for Deprotection of Silyl Ethers UsingSBA-15—SO_3H or Silica Sulfuric Acid

作　　者：李英芝[1] 彭家建[1] 白赢[1] 厉嘉云[1] 肖文军[1] 

机构地区：[1]杭州师范大学有机硅化学及材料技术教育部重点实验室,浙江杭州311121

出　　处：《杭州师范大学学报（自然科学版）》2015年第6期561-566,共6页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：Supported by the National Natural Science Foundation of China(21303034);National Natural Science Foundation of Zhejiang Province(LY14B030007)

摘　　要：官能团的保护和脱保护是诸多多步有机化学反应必须涉及的.文章报道了在温和条件下,磺酸功能化的介孔材料(SBA-15—SO3H)以及硅胶负载硫酸(SSA)均是有效的叔丁基二甲基硅基醚保护基团的脱保护催化剂.SBA-15—SO3H的循环使用效果优于SSA,而SSA的催化活性高于SBA-15—SO3H.Protection/deprotection of functional groups are widely used for multistep organic reactions.This paper indicates that under mild conditions,sulfonic acid-functionalized mesoporous（SBA-15—SO3H）and silica sulfuric acid（SSA）are used as efficient catalysts to the deprotection of tert-butyldimethylsilyl（TBDMS）ethers.Particularly,the recycling usage effect of SBA-15—SO3H is better than SSA,while the catalytic activity of SBA-15—SO3H is less than SSA.

关 键 词：SBA-15—SO3H 硅胶硫酸 脱保护 

分 类 号：TQ426.6[化学工程]