冠状动脉支架置入术后支架内再狭窄的影响因素（英文）  

Influencing factors of in-stent restenosis after coronary artery stent implantation

作　　者：龚斐[1] 干学东[1] 丁进叶 万静[1] 

机构地区：[1]武汉大学中南医院心内科,湖北武汉430071

出　　处：《心血管康复医学杂志》2015年第6期593-596,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：National Natural Science Fund(81000119)~~

摘　　要：目的:分析冠状动脉支架置入术后支架内再狭窄的影响因素,为临床预防再狭窄提供理论支持。方法:回顾性分析自2011年3月至2013年9月在我院行冠脉支架置入术,并于术后1年行冠脉造影随访的123例患者的临床资料。以置入支架内径狭窄≥50%为再狭窄,分为再狭窄组(35例)和无再狭窄组(88例)。采用多因素Logistic回归分析分析冠脉支架内再狭窄的影响因素。结果:与无再狭窄组比较,再狭窄组血清总胆红素水平[(14.02±6.76)μmol/L比(10.90±4.51)μmol/L]显著降低、支架直径[(3.06±0.86)mm比(2.87±0.44)mm]显著减小,P均<0.01。多因素Logistic回归分析结果显示,血糖水平是冠状动脉支架术后再狭窄的独立危险因素(OR=2.545,P=0.035),而支架直径和血清总胆红素水平是其保护因素(OR=0.857,0.850,P=0.044,0.042)。结论:血糖水平是冠状动脉支架内再狭窄的危险因素,支架直径和血清总胆红素水平是其保护因素。Objective： To analyze influencing factors of in-stent restenosis after coronary artery stent implantation, to provide theoretical support for clinical prevention of restenosis. Methods： Clinical data of 123 patients, who re- ceived coronary artery stent implantation in our hospital from Mar 2011 to Sep 2013 and received coronary angiography follow-up one year after operation, were retrospectively analyzed. In-stent restenosis was regarded as stenosis of inner diameter of implanted stent ≥50%, so patients were divided into restenosis group （n = 35） and non-restenosis group （n = 88）. Multi-factor Logistic regression analysis was used to analyze influencing factors of coronary in-stent restenosis. Results： Compared with non-restenosis group, there were significant reductions in serum level of total bilirubin [（14.02±6.76） μmol/L vs. （10.90±4. 51） μmol/L] and stent diameter [ （3.06± 0.86） mm vs. （2.87±0.44） mini in restenosis group, P〈0.01 both. Multi-factor Logistic regression analysis indicated that blood glucose level was independent risk factor for restenosis after coronary artery stent implantation （OR = 2. 545, P = 0. 035）, while stent diameter and serum level of total bilirubin were its protective factors （OR = 0. 857, 0.850, P = 0.044, 0.042）. Conclusion.. Blood glucose level is an independent risk factor for restenosis after coronary artery stent implantation, while stent diameter and serum level of total bilirubin are its protective factors.

关 键 词：冠状动脉再狭窄 支架 危险因素 

分 类 号：R541.409[医药卫生—心血管疾病]