糖尿病患者血糖水平与肱踝脉搏波传导速度及hsCRP水平的关系  

Relationship among brachial ankle pulse wave velocity,hsCRP level and blood glucose level in patients with diabetes mellitus

作　　者：王伟红[1] 邓正聪[2] 靳雪芹[3] 

机构地区：[1]塔里木油田医院体检中心,新疆库尔勒841000 [2]塔里木油田医院内二科,新疆库尔勒841000 [3]江汉大学

出　　处：《心血管康复医学杂志》2015年第6期603-605,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：巴音郭楞蒙古自治州2013年星火计划项目(201310)~~

摘　　要：目的:研究2型糖尿病患者血糖水平与肱踝脉搏波传导速度(baPWV)及高敏C反应蛋白(hsCRP)水平的关系。方法:选择2型糖尿病患者102例,健康体检者60例(正常对照组)为研究对象,根据糖化血红蛋白水平2型糖尿病患者被分为:HbA1c正常组(44例,HbA1c≤6.5%)和HbA1c升高组(58例,HbA1c>6.5%),检测各组患者的baPWV及血脂、血糖及hsCRP水平,并进行比较。结果:与正常对照组比较,HbA1c正常组和HbA1c升高组hsCRP水平[(1.82±0.2)mg/L比(2.7±0.1)mg/L比(3.5±0.1)mg/L]均显著升高,baPWV[(1412±95)cm/s比(1755±72)cm/s比(2040±105)cm/s]显著增加(P均<0.05),且HbA1c升高组hsCRP水平和baPWV显著高于HbA1c正常组(P均<0.05)。结论:2型糖尿病患者肱踝脉搏波传导速度和高敏C反应蛋白水平明显高于正常者,且血糖控制不理想者的明显高于血糖控制理想者的,积极控制患者血糖可延缓动脉粥样硬化进展。Objective： To study the relationship among brachial ankle pulse wave velocity （baPWV）, level of high sensitive C reactive protein （hsCRP） and blood glucose level in patients with type 2 diabetes mellitus （T2DM）. Methods： A total of 102 T2DM patients and 60 healthy people undergoing physical examination （normal control group） were selected. According to level of glycosylated hemoglobin （HbA1c）, T2DM patients were divided into normal HbAlc group （n = 44, HbA1c≤6. 5%） and HbA1c elevating group （n = 58, HbAlc〉6.5%）. BaPWV, levels of blood lipids, blood glucose and hsCRP were measured and compared among above groups. Results： Compared with normal control group, there were significant rise in hsCRP level F（1.82± 0.2） mg/L vs. （2.7±0.1） mg/L vs. （3.5±0.1） mg/L] and baPWV[（1412±95） cm/s vs. （1755±72） cm/s vs. （2040 ±105） cm/s] in normal HbAlc group and HbAlc elevating group （P〈0. 01 all）, and hsCRP level and baPWV of HbAlc elevating group were sig- nificantly higher than those of normal HbAlc group, P〈0.05 both. Conclusion： Brachial ankle pulse wave velocity and level of hsCRP of patients with type 2 diabetes mellitus are significantly higher than those of normal subjects, and those of patients with poor blood glucose control are significantly higher than those of patients with good blood glucose control. Active blood glucose control can delay atherosclerosis progress.

关 键 词：糖尿病 2型 血红蛋白A 糖基化 C反应蛋白质 

分 类 号：R587.109[医药卫生—内分泌]