老年男性慢性心衰患者血浆睾酮与心功能和炎症的相关性  

Correlation among cardiac function,inflammation factor and plasma testosterone level in aged male patients with chronic heart failure

作　　者：殷文 刘海燕 王浩宇 刘涛 陈世蓉 

机构地区：[1]南充市中心医院心血管内科,四川南充637900

出　　处：《心血管康复医学杂志》2015年第6期620-622,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察老年男性慢性心力衰竭(CHF)患者血浆睾酮与心功能和相关炎症因子水平的相关性。方法:选择我院住院CHF男性患者91例(NYHAⅡ级31例、Ⅲ级30例、Ⅳ级30例)和与之相匹配的男性无CHF患者40例作为无CHF对照组,比较两组血浆睾酮、白介素(IL)-6、肿瘤坏死因子(TNF)-α、脑利钠肽(BNP)水平及心功能的差异。结果:与无CHF对照组相比,CHF各亚组血浆睾酮水平均显著下降(P<0.05或<0.01),且随着NYHA心功能等级的增加而降低(P<0.05或<0.01);相关分析显示:睾酮水平与IL-6、TNF-α水平呈负相关(r=-0.244、-0.322,P均<0.05),与LVEF呈正相关(r=0.322,P=0.01)。结论:慢性心力衰竭患者心功能越差,血浆睾酮水平越低,测定睾酮水平有助于判断慢性心衰患者心衰的程度及预后情况。Objective： To observe the correlation among cardiac function , inflammation factor and plasma testoster- one level in aged male patients with chronic heart failure （CHF）. Methods： A total of 91 male CHF inpatients were selected from our hospital, including 31 cases with NYHA cardiac function class Ⅱ, 30 cases with class Ⅲ and 30 ca- ses with class IV. Another 40 corresponding male patients without CHF were regarded as non-CHF control group. Plasma levels of testosterone, interleukin （IL） -6, tumor necrosis factor （TNF） - α and brain natriuretic peptide （BNP） and cardiac function were compared between two groups. Results： Compared with non-CHF control group,there were significant reductions in plasma testosterone level, P〈0.05 or 0.01, and they more reduced along with NYHA cardiac function class rose in all CHF subgroups, P〈0.05 or 〈0.01. Correlation analysis indicated that testosterone level was inversely correlated with IL-6 and TNF-α levels （ r = - 0. 244, - 0. 322, P〈0.05 both）, and positively correlated with LVEF （r = 0. 322, P = 0.01）. Conclusion： In patients with chronic heart failure, the poorer cardiac function is, the lower plasma testosterone level is. Testosterone level measurement contributes to judging disease degree and prognosis of patients with chronic heart failure.

关 键 词：睾酮 心力衰竭 炎症 

分 类 号：R541.6[医药卫生—心血管疾病]