氨氯地平对原发性高血压患者炎症因子水平的疗效  

Therapeutic effect of amlodipine on inflammatory factor levels in patients with essential hypertension

作　　者：邓东波[1] 袁斌[1] 

机构地区：[1]湖北省荆州市第二人民医院心内科,湖北荆州434000

出　　处：《心血管康复医学杂志》2015年第6期659-661,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察马来酸左旋氨氯地平对原发性高血压(EH)患者炎症因子水平的疗效。方法:采用随机数字表法,84例EH患者被随机均分为硝苯地平组(接受硝苯地平治疗)和氨氯地平组(接受马来酸左旋氨氯地平治疗),两组均连续服药12周。治疗前后分别检测两组患者血压、血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和高敏C反应蛋白(hsCRP)水平,并进行比较。结果:治疗前,两组患者血压及血清TNF-α、IL-6和hsCRP水平比较,差异无显著性(P>0.05);治疗后,两组各指标均较治疗前显著降低(P均<0.01),且与硝苯地平组比较,氨氯地平组患者收缩压[(136.9±13.4)mmHg比(128.3±12.5)mmHg]、舒张压[(88.4±7.1)mmHg比(82.7±6.8)mmHg]、血清TNF-α[(10.85±2.56)ng/L比(8.61±2.37)ng/L]、IL-6[(18.92±4.61)ng/L比(13.73±4.18)ng/L]和hsCRP水平[(7.95±2.38)mg/L比(5.89±2.24)mg/L]均显著下降,差异均有显著性(P均<0.01)。结论:马来酸左旋氨氯地平较硝苯地平更能显著降低原发性高血压患者TNF-α、IL-6和hsCRP水平,抑制炎症反应,有益于血压控制。Objective： To observe therapeutic effect of maleic acid levamlodipine （amlodipine） on inflammatory factor levels in patients with essential hypertension （EH）. Methods： According to random number table method, a total of 84 EH patients were randomly and equally divided into nifedipine group （received nifedipine treatment） and amlodipine group （received maleic acid levamlodipine treatment）, both groups were treated for 12 weeks. Blood pressure, serum levels of tumor necrosis factor α（TNF-α）, interleukin-6 （IL-6） and high sensitive C reactive protein （hsCRP） were measured and compared between two groups before and after treatment. Results： Before treatment, there were no significant difference in blood pressure, serum levels of TNF-α, IL-6 and hsCRP between two groups, P〉0.05; after treatment, all above indexes significantly reduced in both groups compared with before treatment, P〈0.01 all. Compared with nifedipine group, there were significant reductions in systolic blood pressure [（136.9 ±13.4） mmHgvs. （128.3±12.5） mmHg], diastolic blood pressure [ （88.4±7.1） mmHg vs. （82.7±6.8） mmHg], serum levels of TNF-α [ （10.85±2.56） ng/L vs. （8.61±2.37） ng/L], IL-6 [ （18.92±4.61） ng/L vs. （13.73±4.18） ng/L] and hsCRP [（7.95±2.38） mg/L vs. （5.89±2.24） mg/L] in amlodipine group, P〈0.01 all. Conclusion： Amlodipine can more significantly reduce levels of TNF-α, IL-6 and hsCRP, inhibit inflammatory reaction than those of nifedipine and contribute to blood pressure control in patients with essential hypertension.

关 键 词：高血压 炎症 氨氯地平 

分 类 号：R544.1[医药卫生—心血管疾病]