多黏菌素类抗生素的肾毒性  

Nephrotoxicity of polymyxins

作　　者：孟现民[1] 董平[1] 张永信[2] 

机构地区：[1]上海市公共卫生临床中心药剂科,上海201508 [2]复旦大学附属华山医院感染科,上海200040

出　　处：《上海医药》2015年第23期18-21,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：多耐药和泛耐药革兰阴性菌所致感染治疗已是临床医生必须直面的挑战。由于缺乏有效的治疗药物,曾因毒性大而被限制使用的多黏菌素类抗生素的临床应用逐渐增多。但因忌惮于肾毒性,加之临床使用经验不足,许多医生对使用多黏菌素类抗生素治疗仍心存顾虑,间接降低了此类药物的临床地位。为更充分地认识多黏菌素类抗生素的肾毒性,本文就此类药物的肾毒性发生机制、临床研究进展和防治作一综述。Treatment of bacterial infection caused by Gram negative bacteria with multiple drug resistance or even pan drug resistance becomes more and more difficult for doctors around the world. Because of the lack of effective antibiotics, the usage of polyrnyxins, which has been limited in clinical application due to toxicity, is becoming more and more often. On the other hand, the doctors are still nervous when using this kind of drug due to fearing the nephrotoxicity ofpolymyxins and lacking clinical experience, which results in the decline of its clinical value indirectly. For fully understanding the nephrotoxicity of polymyxins, the mechanism and prevention of nephrotoxicity and the research progress in the clinical application of polymyxins are summarized in this review.

关 键 词：多黏菌素类抗生素 肾毒性 防治措施 

分 类 号：R961[医药卫生—药理学]