手性配体交换色谱的研究进展  

Study Progress of Chiral Ligand Exchange Chromatography

作　　者：王小平[1] 沈芒芒[1] 童胜强[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032

出　　处：《分析测试学报》2015年第12期1446-1450,共5页Journal of Instrumental Analysis

基　　金：国家自然科学基金(21105090);浙江省高等学校中青年学科带头人攀登项目(pd2013031)

摘　　要：手性配体交换色谱技术将配体交换原理与色谱技术相结合,拓宽了液相色谱、电泳以及逆流色谱的应用层面,为部分难分离手性物质提供了有效的分离与检测方法。该文参考了近年来国内外的相关文献,综述了手性配体交换技术在液相色谱、电泳与逆流色谱等领域中的应用进展;总结了手性配体交换色谱技术的基本原理、影响因素、优缺点等,并对手性配体交换色谱技术的趋势进行了展望。Chiral ligand exchange chromatography is a kind of technique which combines ligand exchange principle with chromatography. The development of chiral ligand exchange strategy has extended the applications of high performance liquid chromatography,electrophoresis and high speed counter current chromatography. This method provides an effective way for the enantioseparation of racemates which are difficult to be enantioseparated by other methods. Applications of chiral ligand exchange in liquid chromatography,electrophoresis and high speed counter current chromatography are summarized. The basic principle,effecting factors,advantages and disadvantages of chiral ligand exchange chromatography are systematically reviewed. Finally,the development trends of chiral ligand exchange chromatography are proposed.

关 键 词：配体交换 液相色谱 电泳 逆流色谱 研究进展 综述 

分 类 号：O657.7[理学—分析化学] G353.11[理学—化学]