大孔吸附树脂分离纯化结晶母液中的3-甲基黄嘌呤  

Separation and Purifi cation of 3-Methylxanthine from Crystallization Mother Liquor with Macroporous Adsorption Resin

作　　者：石磊[1] 田玉妙 于文国[1] 刘清涛[1] 赵旭 

机构地区：[1]河北化工医药职业技术学院,河北石家庄050026 [2]石药集团新诺威制药股份有限公司,河北石家庄051430

出　　处：《中国医药工业杂志》2015年第12期1347-1351,共5页Chinese Journal of Pharmaceuticals

基　　金：河北省高等学校科学研究青年基金项目(QN20131108)

摘　　要：考察大孔吸附树脂分离纯化结晶母液中3-甲基黄嘌呤的最佳工艺。利用静态吸附试验筛选5种大孔吸附树脂,并通过动态吸附及解吸的单因素影响试验,优选树脂的最佳分离纯化条件。结果表明,大孔吸附树脂HZ16较适用于分离纯化结晶母液中的3-甲基黄嘌呤,其静态吸附量约18 mg/ml。用5%乙醇和60%乙醇(p H 10.0)可以解吸树脂柱上的3-甲基黄嘌呤,平均解吸收率大于92%。The optimal process was investigated and established for the separation and purification of 3-methylxanthine from crystallization mother liquor with macroporous adsorption resin. Five kinds of macroporous resins were screened by static adsorption test. The optimal purification conditions were obtained based on dynamic adsorption and desorption. The results showed that HZ16 resin was an optimal macroporous adsorbent for the separation and purification of 3-methylxanthine from crystallization mother liquor. Its adsorption capacity for 3-methylxanthine was about 18 mg/ml. 3-Methylxanthine could be effectively desorbed by 5 % and 60 % ethanol （pH 10.0）. The average yield of desorption was over 92 %.

关 键 词：3-甲基黄嘌呤 大孔吸附树脂 吸附 解吸 分离纯化 

分 类 号：TQ465[化学工程—制药化工] R917[医药卫生—药物分析学]