半微量合成阿司匹林实验改进  

Improving Experiment on Semimicro Synthesis of Aspirin

作　　者：陈林[1] 余正萍[1] 

机构地区：[1]四川化工职业技术学院制药与环境工程系,四川泸州646005

出　　处：《广东化工》2015年第24期75-75,68,共2页Guangdong Chemical Industry

摘　　要：本实验以水杨酸和乙酸酐为原料,以维生素C为催化剂,35%乙醇水溶液为重结晶溶剂合成阿司匹林。实验结果表明在该实验条件下收率可达83.08%,与同等条件下以浓硫酸为催化剂,饱和Na HCO3溶液为重结晶溶剂相比,收率提高了18%左右。Aspirin was synthesized using raw materials of salicylic acid and Acetic anhydride, which was catalyzed by Vitamin C and recrystallized by Ethanol solution of 35 percent. The results were showed that yield of aspirin was reached 83.08 percent. Compared with catalysis by concentrated sulfuric acid and recrystallization by saturated sodium carbonate solution, yield of aspirin was enhanced about 18 percent at status conditions.

关 键 词：阿司匹林 半微量合成 水杨酸 乙酸酐 

分 类 号：TQ[化学工程]