超声诊断颈动脉狭窄与血清骨桥蛋白水平关系的临床研究  

Association of serum osteopontin and carotid stenosis determined by carotid ultrasound

作　　者：王晓瑛[1] 陈静[1] 闫艳[1] 王晓萍[1] 杨新新[2] 

机构地区：[1]徐州医学院附属医院心脏彩超室,江苏徐州221002 [2]徐州医学院附属医院神经内科

出　　处：《徐州医学院学报》2015年第10期705-707,共3页Acta Academiae Medicinae Xuzhou

基　　金：国家自然科学基金（81301077）

摘　　要：目的：探讨动脉粥样硬化性颈动脉狭窄与血清骨桥蛋白水平间的关系。方法选取我院住院及门诊经颈动脉彩超筛查的动脉粥样硬化性颈动脉狭窄患者80例，设为颈动脉狭窄组，同时选取年龄、性别相匹配的健康体检者80例，设为非颈动脉狭窄组，检测颈动脉狭窄组患者颈动脉斑块的特点，同时记录和检测2组人群的年龄、性别、收缩压、低密度脂蛋白、空腹血糖、同型半胱氨酸水平、体重指数（ BMI）等，此外，利用ELISA方法检查两组人群血清中骨桥蛋白水平。结果80例颈动脉狭窄患者中，稳定斑块34例，不稳定斑块46例。与非颈动脉狭窄组比较，颈动脉狭窄组患者的收缩压、低密度脂蛋白、空腹血糖、同型半胱氨酸水平、BMI均明显升高（ P均＜0．05）；颈动脉狭窄组患者的血清骨桥蛋白水平较非颈动脉狭窄组高（ P＜0．01）。多元逐步回归分析表明颈动脉狭窄与患者的性别、低密度脂蛋白、骨桥蛋白水平有关（B＝0．022～0．047，P均＜0．05）。结论血清骨桥蛋白可能参与了颈动脉粥样硬化的形成。Objective To investigate the relationship between serum steopontin and atherosclerotic carotid stenosis. Methods A total of 80 patients who were diagnosed with atherosclerotic carotid stenosis by carotid ultrasound were in-cluded in this study.Meanwhile, another 80 age and sex-matched healthy subjects were also enrolled as controls.The characteristics of carotid plaques in patients with atherosclerotic carotid stenosis were detected.Then, both groups were compared for age, gender, systolic blood pressure, low density lipoprotein, fasting blood glucose, homocysteine levels and body mass index （ BMI） .The levels of serum osteopontin in patients of both groups were measured by ELISA.Re-sults Among the patients with atherosclerotic carotid stenosis were 34 patients with stable plaques and 46 ones with un-stable plaques.Compared with the control, remarkably increases were observed as to systolic blood pressure, low density lipoprotein, fasting blood glucose, homocysteine level and BMI in the atherosclerotic carotid stenosis group （ all P 〈0.05）.The atherosclerotic carotid stenosis group also produced higher quantities of serum osteopontin, in comparison with the control （P〈0.01）.According to multiple stepwise regression analysis, atherosclerotic carotid stenosis was cor-related with patients′gender, and the levels of low density lipoprotein and osteopontin （ B=0.022 -0.047, all P〈0.05）.Conclusion Osteopontin may be involved in the formation of atherosclerotic carotid stenosis.

关 键 词：颈动脉彩超 斑块 骨桥蛋白 

分 类 号：R445.1[医药卫生—影像医学与核医学]