低频超声联合造影剂微泡对前列腺组织中头孢呋辛浓度的影响  

Effect of low-dose ultrasound-mediated microbubble on the concentration of cefuroxime in rat prostate

作　　者：尚永刚[1] 韩广玮[1] 董小小[2] 崔栋[1] 刘城城[1] 易善红[1] 

机构地区：[1]第三军医大学新桥医院泌尿外科,重庆400037 [2]第三军医大学新桥医院超声诊断科,重庆400037

出　　处：《局解手术学杂志》2015年第6期602-605,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：第三军医大学新桥医院临床科研基金(2014YLC27)

摘　　要：目的观察微泡介导下低频超声辐照对大鼠前列腺组织中药物浓度的影响。方法选取健康成年雄性SD大鼠20只,随机平均分为实验组(超声微泡+头孢呋辛组)及对照组(头孢呋辛组)。实验组经尾静脉注射头孢呋辛及微泡后立即以低频超声辐照前列腺5 min;对照组经尾静脉注射头孢呋辛及与实验组微泡等量的生理盐水后立即对前列腺进行超声假照5 min。辐照结束后取出前列腺,进行组织匀浆,高效液相色谱仪测定前列腺组织中头孢呋辛含量。结果实验组与对照组单位质量前列腺组织中头孢呋辛浓度分别为(16.274±9.515)μg/mg、(8.336±6.743)μg/mg,实验组单位质量前列腺组织中头孢呋辛浓度明显高于对照组,差异具有统计学意义(P<0.05)。结论低频超声联合造影剂微泡可显著提高大鼠前列腺组织的通透性,从而提高前列腺组织中的药物浓度。Objective To study the effect of ultrasound-mediated microbubble on the concentration of cefuroxime in rat prostate. Methods Twenty male SD rats were randomly divided into the experimental group （ultrasound-mediated mierobubble ＋ eefuroxime group） and the control group （cefuroxime group）. The experimental group was given cefuroxime and microbubble via the tail vein, and then the prostates were exposed to ultrasonic irradiation for five minutes. The control group was given cefuroxime and the same amount of normal salin via the tail vein, and then given sham ultrasonic irradiation for five minutes. After the prostate was taken, cefuroxime concentration in pros- tate was measured by high performance liquid chromatograph. Results Concentration of cefuroxime in the experimental and the control group were （ 16.274±9.515 ） μg/mg and （8. 336 ± 6.743 ） μg/mg respectively. Compared to the control group, the concentration of cefuroxime was significant higher in the experimental group, and the difference is statistically significant （ P 〈 0.05 ）. Conclusion Low-dose ultra- sound-mediated microbubble can significantly improve the permeability of rat prostate tissue, thereby enhancing the drug concentration in prostate tissue.

关 键 词：慢性前列腺炎 微泡 超声辐照 头孢呋辛 

分 类 号：R697.33[医药卫生—泌尿科学] R781.42[医药卫生—外科学]