COX-2/Nrf2信号通路在防治前列腺增生症中的研究进展  

Research Progress of COX-2/Nrf2 Signaling Pathway in Prevention and Treatment of Benign Prostatic Hyperplasia

作　　者：全丹妮 颜苗[2] 樊新荣[1,3] 邓阳[1,2] 胡乔铭[1] 刘文琛[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]中南大学湘雅二医院药学部中南大学临床药学研究所,湖南长沙410011 [3]中国中医科学院,北京100700

出　　处：《湖南中医药大学学报》2015年第11期70-72,F0003,共4页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金(81373708;81202985)

摘　　要：前列腺增生症(benign prostatic hyperplasia,BPH)目前是困扰全球中老年男性最主要的泌尿系统疾病,以下尿路症状为主要临床表现,对患者的生活质量造成了严重的影响。近年来COX-2/Nrf2信号通路的抗炎、抗氧化应激作用得到了证实,炎症及氧化应激在BPH发展过程中的细胞生物学机制也逐渐被阐明,中药基于COX-2/Nrf2信号通路对BPH防治作用得到研究者的关注。本文对COX-2/Nrf2信号通路在防治BPH中的研究进展进行相关阐述。Benign prostatic hyperplasia （BPH） is the most important diseases of urinary system in middle-aged males, and its main clinical manifestations is urinary tract symptoms, which has serious impact on life quality of patients. In recent years, the effects of anti-inflammatory and anti-oxidative stress of COX-2/Nrf2 signaling pathway were demonstrated. The cell biological mechanisms of inflammation and oxidative stress in the development of BPH has been elucidated. Based on the COX-2/Nrf2 signal pathway, the research of Chinese medicine prevention and treatment of BPH get the attention of us. This paper elaborates the progress of COX-2/Nrf2 signaling pathway in the prevention and treatment of BPH.

关 键 词：前列腺增生症 COX-2/Nrf2 抗炎 抗氧化 

分 类 号：R277.5[医药卫生—中医学]