阻塞性睡眠呼吸暂停低通气综合征与高血压关系24年随访  

The correlation betw een obstructive sleep apnea hypopnea syndromeand and Hypertension

作　　者：朱爱华[1] 杨燕玲[2] 刘春君[3] 戴煌[1] 王预建 徐状[1] 慈书平[1] 

机构地区：[1]解放军第359医院老年病科,镇江212001 [2]解放军第113医院,宁波315040 [3]解放军第322医院,大同037600

出　　处：《世界睡眠医学杂志》2015年第3期171-174,共4页World Journal of Sleep Medicine

基　　金：南京军区"十一五"医药卫生科研基金课题(编号:06MA70)

摘　　要：目的 随访阻塞性睡眠呼吸暂停低通气综合征 （ OSAHS） 与高血压的关系. 方法 对1 868例人群进行前瞻性随访, 通过家访式调查, 随访期间每年进行1次体检, 检查血压、 血脂、 血糖、 心电图及X线胸片等, 随访时间为24年. 结果 1 868例中男性956例、 女性912例, 随访起点年龄范围53~82岁, 平均年龄 （ 63 ±6 ） 岁. 其中确诊OSAHS者598 （32.0%） 例, 无OSAHS （对照组） 1 270 （68.0%） 例. 随访终点OSAHS组高血压506 （84.6%） 例、对照组398 （31.3%） 例, P〈0.01. 结论 OSAHS患者发生高血压可能性较一般人群高, 考虑OSAHS与发生高血压存在相关性. 通过24年随访, 提示OSAHS可能是高血压病的独立危险因素. 引起高血的机制可能与OSAHS导致的低氧血症等有关.Objective To explore the correlation between obstructive sleep hypopnea apnea syndrome（ OSAHS） and hypertension.Methods Prospective Home-visit questionaires for 1 868 people were used from November 1989 to November 2013,accompanied by annual medical examinations including blood pressure, blood-fat, serum glucose, electrocardiogram and chest x-ray.Computer tomography was carried out When hypertension manifested,that was termination of follow-up,the period of follow-up lasted 24 years.Results Among 1 868 elderly people,598（32.0%）OSAHS patients were made.1 270（68.0%）non-OSAHS group.patients who developed into hypertension were 506/598（84.6%）in OSAHS group,and 398/1 270（31.3%）,P〈0.01）in non-OSAHS group,respectively.943 died at last in the course of 24 years,431/598（72.1%）in OSAHS group and 512/1 270（40.3%,P〈0.01）in non-OSAHS group,respectively.Conclusion According to longtime follow-up,the probability of OS-AHS patients suffers from hypertension is larger than the normal.We consider that there is a correlation between OSAHS and hy-pertension.At the end of our 24 years follow-up,OSAHS may be an independent dangerous factor of hypertension.

关 键 词：睡眠呼吸暂停低通气综合征 阻塞性 高血压病 流行病学 随访 

分 类 号：R766.43[医药卫生—耳鼻咽喉科]