TCu220C宫内节育器妊娠率及其影响因素meta分析  

A meta-analysis of the association between pregnancy rate and its influence factors of TCu220C

作　　者：林洁[1] 陈颖[1] 李瑛[1] 

机构地区：[1]江苏省计划生育科学技术研究所,南京210036

出　　处：《中国计划生育学杂志》2015年第12期796-801,共6页Chinese Journal of Family Planning

基　　金：国家卫生计生委卫生技术评估项目(20140603)

摘　　要：目的:运用meta分析方法评价TCu220C宫内节育器(IUD)的带器妊娠率及其影响因素,通过与其它含铜IUD的比较,对TCu220CIUD有效性进行综合评估。方法:采用计算机检索PubMed、EMBASE、CENTRAL等9种数据库和WHO/FDA/IUD生产企业/临床试验注册相关网站,采用Openmeta analyst和RevMan5.3.3进行数据的分析与合并。结果:共检索到7726篇文献,根据纳入及排除标准,最终纳入31篇文献,均为随机对照试验(RCT)或准RCT。分析1第1、2年国内TCu220C的妊娠率均高于国外,第10年国内TCu220C的妊娠率与国外相近,差异均未显著性。2TCu220C在不同放置时期妊娠率自然流产后放置最低,哺乳期置器最高,但差异无统计学意义。3年龄对放置TCu220C后妊娠率无影响。4在第2年随访时TCu220C的妊娠率低于MLCu250(P<0.05),在第1、2年随访时,TCu220C的妊娠率低于金属单环(P<0.05);而TCu220C与活性165、MCuⅡ、活性γ型、爱母型、V铜、宫铜300、MLCu375、TCu380A等8种IUD妊娠率比较差异均无统计学意义。结论:本研究首次报道TCu220C的妊娠率与不同地区、放置时期和放置年龄关系的meta分析结果,未见TCu220C的妊娠率与地区、放置时期和对象年龄之间的关系;IUD的铜表面积大小与妊娠率高低的规律未在本研究中得到证实,有待更多研究认证。Objective： To evaluate the association between pregnancy rate of TCu220C IUD and its influence factors , and to compare pregnancy rate of TCu220C and other copper-bearing IUDs, and to assess the effectiveness of TCu220C IUD. Methods： 9 electronic databases （PubMed, EMBASE, CENTRAL, etc.） and several related websites （ClinicalTrials, Current Controlled MetaRegister, Chinese clinical trial registry, WHO, FDA, Bayer, Wyeth） were searched. Software of Open Meta-analyst and RevMan5.3.3 were used to analysis and incorporate of data. Results： 7726 Chinese and English literatures were searched preliminarily, but only 31 RCTs and quasi RCTs of TCu220C IUD were recruited for further analysis according to the inclusion and exclusion criteria. The results showed that：①The pregnancy rate of TCu220C in China was higher than that of other countries in the first and second year follow-up after IUD inserted, but it was very similar in the 10th year follow-up. There was no significant difference in pregnancy rates of TCu220C between that in China and in other countries（P〉0.05）.②There was no significant difference in pregnancy rates of TCu220C when comparing insertion after spontaneous abortion to lactation period abortion. ③There was no significant difference in pregnancy rates of TCu220C among different age women.④The pregnancy rate of TCu220C was significantly lower than that of MLCu250 at the time of 2 years follow-up, and also was lower than that of Stainless Steel Ring at the time of 1 and 2 years follow-up. While pregnancy rates of TCu220C compared to active-165, MCuⅡ, active-γ, MCu, VCu, Uterine-shaped copper 300, MLCu375, or TCu380A, there was no significant difference. Conclusion： This meta -analysis is the first time to explore the association between the pregnancy rate of TCu220C and its influence factors. The result showed that the pregnancy rate of TCu220C was not affected by used in different country, IUD inserting time, or age of woman. There was no any evidence implied pregnancy r

关 键 词：TCU220C 宫内节育器 妊娠率 META分析 

分 类 号：R169.4[医药卫生—公共卫生与预防医学]