手性萃取剂与液-液萃取拆分对映体技术研究进展  

Chiral extractants and enantioselective liquid-liquid extraction

作　　者：黄钰清[1] 鲍宗必[1] 邢华斌[1] 杨亦文[1] 张治国[1] 任其龙[1] 

机构地区：[1]生物质化工教育部重点实验室浙江大学化学工程与生物工程学院,浙江杭州310027

出　　处：《化工进展》2015年第12期4324-4332,共9页Chemical Industry and Engineering Progress

基　　金：浙江省教育厅科研项目(Y201016430);国家自然科学基金(21376205);浙江省自然科学基金(Y13B060004)项目

摘　　要：手性对映体的拆分是当前备受关注的一个研究领域。手性对映体的拆分方法有多种,手性液-液萃取拆分法是其中有较好发展前景的一种手性对映体拆分技术。本文概述了手性液-液萃取技术的基本原理,并进一步对酒石酸类手性萃取剂、环糊精类手性萃取剂、冠醚类手性萃取剂、金属络合物类手性萃取剂等不同种类手性萃取剂及其研究进展进行了综述。分析表明,手性液-液萃取拆分技术对外消旋体特别是药物外消旋体的拆分有较好的效果,随着对手性萃取剂研究的进一步深入,手性液-液萃取有望成为一种手性化合物拆分的重要方式。Techniques for separating enantiomers are the focus of concern currently. Among numerous techniques for separating enantiomers,such as crystallization,chromatography,enantioselective liquid-liquid extraction is one of the most promising techniques for industrial application. This review firstly introduced the basic principles of the enantioselective liquid-liquid extraction technique,and then summarized various chiral extractants including tartrates-based extractants,cyclodextrin-based extractants, crown ether based-extractants, metal complexes-based extractants, and other enantioselective extraction agents as well as their recent advances. Researches indicate that enantioselective liquid-liquid extraction shows remarkable enantioseparation ability for enantiomers especially racemic pharmaceuticals. With the developing of new chiral extractants,enantioselective liquid-liquid extraction can be an important technique for enantiomers separation.

关 键 词：手性萃取剂 萃取分离 手性拆分 药物 

分 类 号：TQ460.6[化学工程—制药化工]