质子转移反应质谱在呼气检测领域的研究进展  

Research Progress of Proton Transfer Reaction Mass Spectrometry in the Field of Breathing Gas Detection

作　　者：赵学玒[1,2] 李维康 杜康[1] 孙运[1] 杨文[3] 汪曣[1,2] 

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津市生物医学检测技术与仪器重点实验室,天津300072 [3]中国环境科学研究院大气环境研究所,北京100012

出　　处：《生物医学工程学杂志》2015年第6期1374-1379,共6页Journal of Biomedical Engineering

基　　金：国家重大科学仪器设备开发专项基金资助(2013YQ090875-2,2013YQ090875-7)

摘　　要：人体呼出的气体携带有重要的生理信息,而呼出气体检测技术具有采样无损、操作便利等优点,是医疗检测领域的研究热点。质子转移反应质谱(PTR-MS)因灵敏度高、响应速度快、特异性好等优点,在呼出气体检测领域发挥着不可替代的作用。本文介绍了PTR-MS的基本原理,综述了PTR-MS在呼出气体检测领域的研究进展,分析了影响测量结果的主要因素,并对其发展方向进行了展望。Breathing gas carries important physiological information. Technology for detection of breathing gas has become a research focus because of the advantages of nondestructive sampling and convenient operation. Proton transfer reaction mass spectrometry （PTR-MS） plays an irreplaceable role because of the advantages of high sensitivity, fast response and good specificity. In this paper, the principle of PTR-MS is introduced first, followed by research progress of PTR-MS in the field of breathing gas detection. Factors influencing the test results are analyzed. Finally, future prospects of development for PTR MS in the field of breathing gas detection are discussed.

关 键 词：呼出气体检测 质子转移反应质谱 易挥发有机化合物 呼气标志物 

分 类 号：R443.6[医药卫生—诊断学] O657.63[医药卫生—临床医学]