上海市某区常见化妆品皮肤不良反应调查及致病成分诊断性斑贴试验分析  

Investigation on cosmetic dermatosis and pathogenic ingredients tested by diagnostic patches in a district of Shanghai City

作　　者：王海俊 谈益妹[2] 施春香 周萍 王宇红 王学民[2] 

机构地区：[1]上海市光华中西医结合医院,上海200052 [2]上海市皮肤病性病医院,上海200050

出　　处：《上海预防医学》2015年第11期704-708,共5页Shanghai Journal of Preventive Medicine

摘　　要：目的明确上海市长宁区化妆品消费人群中发生化妆品不良反应的致病成分,确定长宁区最常见的化妆品致病成分,为找出上海市化妆品皮肤病致病成分提供一线资料。方法采取问卷调查的方式,在长宁区10个社区对化妆品消费人群进行问卷调查,对有化妆品不良反应人群用随机数字表抽取有发病史的志愿者进行化妆品抗原系列诊断性斑贴试验。结果 122例志愿者中,34例斑贴试验呈阳性反应,阳性率为27.87%;阳性率前5位抗原依次为虫胶、硫柳汞、CL+ME-异噻唑、十二烷酸盐和山梨糖醇酐倍半油酸酯;不同类别抗原阳性率前5位依次为防腐剂、着色剂、乳化剂、抗氧化剂和表面活性剂;性别之间、年龄之间阳性率差异无统计学意义。结论斑贴试验是诊断化妆品皮肤病的重要依据,通过大样本调查可确定上海地区常见的化妆品致病成分,建立致病数据库,对于积极预防化妆品皮肤病的发生具有重要意义。Objective To ascertain pathogenic ingredients in cosmetics resulting in dermatosis in Changning District of Shanghai. Methods By means of questionnaire,a survey was done among volunteers,with the history of unwelcome cosmetic reactions in ten communities of Changning District of Shanghai. They received cosmetic series diagnostic patch test. Results Of a total of 122 volunteers,34 were observed with positive reactions,the positive rate being 27. 87%. The top five antigens in positive rates were Shellac,Thimerosal,Methylisothiazolinone ＋ Methylchloro- isothiazolinone,Dodecyl Gallate,and Sorbitan Sesquioleate. Meanwhile,The top five different categories of antigens in positive rates were preservatives,colorants,emulsifying agent,antioxidant and surfactant. There were no significant differences found between genders and ages. Conclusion Patch test is an important basis for diagnosis of cosmetic dermatosis. By large sample investigation,common cosmetic pathogenic ingredients in Shanghai can be determined. Then,pathogenic database can be established,which is important in active prevention of cosmetic dermatosis.

关 键 词：化妆品皮肤病 致病成分 斑贴试验 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]