有机阴离子转运多肽OATP1B1、OATP1B3的基因多态性及其介导的药物相互作用研究进展  

Advances in investigations of gene polymorphisms and drug-drug interactions mediated by organic anion transporting polypeptides OATP1B1 and OATP1B3

作　　者：孙晓琳[1,2] 赵娣[2] 李军袖 郭朝瑞[2] 陈西敬[2] 张广钦[1] 

机构地区：[1]中国药科大学临床药学教研室 [2]中国药科大学药代动力学研究中心

出　　处：《中国临床药理学与治疗学》2015年第11期1296-1301,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然基金资助(81473272)

摘　　要：有机阴离子转运多肤(organic anion transporting polypeptides,OATPs)是一类摄取型转运体。它的特点是在机体内分布广泛,底物众多,其中OATP1B1和OATP1B3主要分布于肝细胞基底侧,在许多药物肝摄取过程中起着重要的作用。所以临床上常出现由其介导的药物相互作用而导致严重的不良反应发生。此外,OATP1B1和OATP1B3具有单核苷酸多态性,可导致其转运功能发生变化从而造成药物作用的个体差异。本文综述了OATP1B1和OATP1B3的单核苷酸多态性及其介导的药物相互作用的最新研究进展。Organic anion transporting polypeptides（OATPs） family are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues.Among them,OATP1B1 and OATP1B3 are mainly localized to the basolateral membrane of hepatocytes,playing important roles in hepatic uptake.Thus,it is common that the severe adverse reactions occur clinically caused by OATP1B1 and OATP1B3 mediated drugdrug interaction.Besides,the single nucleotide polymorphisms of OATP1B1 and OATP1B3 may be contributed to interindividual variability in drug disposition and response.In this review,the single nucleotide polymorphisms of OATP1B1 and OATP1B3 will be summarized,and the potential drug-drug interactions mediated by OATP1B1 and OATP1B3 will also be reviewed.

关 键 词：有机阴离子转运多肽 药物相互作用 单核苷酸多态性 

分 类 号：R968[医药卫生—药理学]