小儿咳喘灵颗粒中金银花的质量分析  

Quality analysis of Lonicerae Japonicae Flos in Xiaoer Kechuanling Granules

作　　者：郑艳青 马斐 张静 刘静 任菲菲 

机构地区：[1]山东省德州市食品药品检验检测中心,山东德州253000

出　　处：《中成药》2015年第12期2660-2664,共5页Chinese Traditional Patent Medicine

摘　　要：目的对26个厂家生产的小儿咳喘灵颗粒(麻黄、金银花、苦杏仁等)中的金银花质量进行系统的研究。方法采用薄层色谱法对样品中的金银花进行定性鉴别;采用HPLC法测定样品中金银花的绿原酸含有量;采用HPLCELSD法测定样品中灰毡毛忍冬皂苷乙的含有量。结果 26批样品中有12批检出灰毡毛忍冬皂苷乙,表明存在原料中掺有山银花的现象。结论测定小儿咳喘灵颗粒中的绿原酸和灰毡毛忍冬皂苷乙,可有助于监控其质量。AIM To systematically evaluate the quality of Lonicerae Japonicae Flos in Xiaoer Kechuanling Granules（ Lonicerae Japonicae Flos,Ephedrae Herba,Radix Isatidis seu Baphicacanthi,etc.） collected from twenty six manufacturers. METHODS The qualitative test for L. Japonicae was conducted by TLC,the content of chlorogenic acid in Xiaoerkechuanling Granules was determined by HPLC,and the content of macranthoidin B was accomplished by HPLC-ELSD. RESULTS The fact of macranthoidin B existence in twelve out of twenty-six batches was indicative of Lonicerae Flos adulteration in raw materials. CONCLUSION Detecting chlorogenic acid and macranthoidin B in Xiaoer Kechuanling Granules can help to monitor the quality of the agent.

关 键 词：小儿咳喘灵颗粒 金银花 绿原酸 灰毡毛忍冬皂苷乙 山银花 薄层色谱法 HPLC法 HPLC-ELSD法 

分 类 号：R927.2[医药卫生—药学]