渝西地区结核病耐药流行状况分析  

Analysis of the prevalence of resistance rate of tuberculosis in Yuxi

作　　者：魏晓宇[1] 田文广[1] 袁喆[2] 

机构地区：[1]重庆医科大学附属永川医院感染科,重庆402100 [2]重庆医科大学附属第一医院感染科,重庆400016

出　　处：《西部医学》2015年第12期1838-1841,共4页Medical Journal of West China

基　　金：重庆市卫生局面上项目(2012-2-177);重庆市永川科委软科学项目(YCSRC;2012BE5009)

摘　　要：目的探讨重庆渝西地区结核病耐药流行状况,为结核病防治提供有效的科学依据。方法采用WHO推荐的药敏比例法对747株临床分离结核分枝杆菌进行药物敏感性试验。结果共747例结核病病例纳入监测分析,总耐药率和耐多药率分别是19.7%和6.8%。初始耐药率和初治耐多药率分别为17.6%和5.5%,复治耐药率和复治耐多药分别为31.8%和14.5%,泛耐药率为0.54%,6种药耐药率顺位由高到低是异烟肼(10.4%)、利福平(10.4%)、链霉素(9.6%)、乙胺丁醇(4.0%)、氧氟沙星(4.6%)和卡那霉素(1.7%)。结论渝西地区结核耐药水平处于中间水平,因此我们应该加强对结核病的管理及治疗。Objective To investigate the prevalence of resistance rate of tuberculosis in Yuxi, Chongqing and pro- vide effective and scientific basis for prevention and control of tuberculosis. Methods The proportional method was used in drug sensitivity test according to the guidelines recommending by WHO. Results The total rate of drug resistance and multi-drug resistance rate were 19.7% and 6.8%. The initial rate of drug resistance and multi-drug resistance rate were 17.6% and 5.5%. The acquired rate of drug resistance and multi-drug resistance rate were 31.8% and 14.5%. The ex- tensive-drug resistance rate was 0.54%. The resistance rate of 6 kinds of anti-tuberculosis drugs were Isoniazid （ 10.4 %）, Rifampicin（ 10.4 % ）, Streptomycin（9.6 % ）, Ethambutol （4.6 % ）, Ofloxacin（4.0 % ） and Kanamycin （ 1.7 % ）. Conclusion The overall drug resistance of tuberculosis still ranks middle level, so we should continue to strengthen man- agement and treatment tuberculosis.

关 键 词：结核病 结核分支杆菌 耐药率 耐多药率 泛耐药率 

分 类 号：R521[医药卫生—内科学] R378.911[医药卫生—临床医学]