sE-选择素和sICAM-1与糖尿病性视网膜病变的相关性研究  

The Relativity Study between Soluble E-selectin and Soluble Intercellular Adhesion Molecule-1 and Diabetic Retinopathy

作　　者：张炜[1] 蔡雷鸣[2] 张燕[3] 杜培宜[3] 谭龙益[2] 王梅芳[1] 张蓉[1] 孙国庆[1] 

机构地区：[1]上海市第一人民医院宝山分院眼科,上海200940 [2]上海市第一人民医院宝山分院检验科,上海200940 [3]上海市第一人民医院宝山分院内分泌科,上海200940

出　　处：《中国医药指南》2015年第36期3-3,9,共2页Guide of China Medicine

基　　金：上海市卫计委(课题:20114143)

摘　　要：目的检测糖尿病性视网膜病变患者血清中sE-选择素和sICAM-1的水平,研究sE-选择素和sICAM-1在糖尿病性视网膜病变发生、发展中的作用及其二者之间的关系。方法选择糖尿病性视网膜病变患者50例;无糖尿病性视网膜病变的2型糖尿病患者100例;年龄、性别相当的正常对照组50例。空腹抽静脉血,采用酶联免疫吸附法(ELISA法)对sE-选择素和sICAM-1进行检测,比较各组之间统计学差异以及sE-选择素和sICAM-1之间的相关性。结果糖尿病性视网膜病变组(A组)和无糖尿病性视网膜病变组(B组)sE-选择素和sICAM-1与对照组(C组)比较均有显著性差异(P<0.01);糖尿病性视网膜病变组(A组)与无糖尿病性视网膜病变组(B组)比较,差异有显著性意义(P<0.01)。糖尿病性视网膜病变组中sE-选择素和sICAM-1呈正相关(r=0.836,P<0.001)。结论 sE-选择素和sICAM-1的测定或许有助于糖尿病性视网膜病变的早期诊断,可能对糖尿病视网膜病变发生和发展有提示意义。Objective To observe the level of serum soluble E-selectin（sE-selectin） and soluble intercellular adhesion molecule-1（sICAM-1） in diabetic retinopathy patients, and to detect the relationship between the sE-selectin and sICAM-1 and the diabetic retinopathy. Methods The serum levels of E-selectin（sE-selectin） and intercellular adhesion molecule-1（sICAM-1） were measured respectively in diabetic retinopathy patients and diabetic patients without diabetic retinopathy as well as normal people. The data were analyzed between the three groups. Results The level of sE-selectin and sICAM-1 in normal group were significantly lower than the diabetic retinopathy patients and diabetic patients without diabetic retinopathy（P〈0.01）. The level of sE-selectin and sICAM-1 in diabetic retinopathy patients were significantly higher than the diabetic patients without diabetic retinopathy（P〈0.01）. The sE-selectin level was positively related to sICAM-1 level in diabetic retinopathy patients（r =0.836, P 〈0.001）. Conclusion The level of sE-selectin and sICAM-1 may be help to the early diagnosis of diabetic retinopathy and may play important roles in reflecting the progress of diabetic retinopathy

关 键 词：SE-选择素 SICAM-1 糖尿病性视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]