2型糖尿病患者联合检测尿mAlb/Cr、NAG、RBP和血Cys-c的意义  

The Value of Combined Detection of Urinary Albumin / creatinine N-acety-beta-D-glucosaminidase,Retinol Binding Protein and Serum Cystatin C in Patients with Type 2 Diabetes

作　　者：周伟[1] 张珏[1] 陈建中[1] 

机构地区：[1]上海中医药大学附属曙光医院检验科,201203

出　　处：《临床输血与检验》2015年第6期486-488,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨联合检测尿白蛋白/肌酐(m Alb/Cr)、尿N-乙酰-β-D氨基葡萄糖酶(NAG)、尿视黄醇结合蛋白(RBP)、血胱抑素C(Cys-c)在2型糖尿病诊疗中的意义。方法根据尿常规蛋白定性将97例2型糖尿病患者分为2组:其中A组54例,尿蛋白定性为阴性,B组43例,尿蛋白定性为弱阳性或阳性。各组均检测尿Alb/Cr、NAG、RBP和血Cys-c。结果 A组尿m Alb/Cr、NAG、RBP和血Cys-c明显高于健康对照组(P<0.05),B组尿m Alb/Cr、NAG、RBP和血Cys-c明显高于A组。A、B两组4项联合检测比多数单项检测阳性率显著提高。结论联合检测尿Alb/Cr、NAG、RBP和血Cys-c有助于提高糖尿病性肾病的早期诊断率及反映肾脏病变的部位。Objective To investigate the value of combined detection of urinary albuminuria/creatinine（ m Alb/Cr） 、Nacety-beta-D-glucosaminidase（ NAG） 、retinol binding protein（ RBP） and serum cystatin C（ Cys C） in type 2 diabetics.Methods According to routine urine test,97 patients were divided into two groups. Group A ha D 54 patients with negative urinary protein test; Group B had 43 patients with positive or weak positive urinary. Urinary Alb / Cr、NAG、RBP and serum Cys C were performed in both groups. Results Urinary Alb / Cr、NAG、RBP and serum Cys C in group A were significantly higher than those in control group（ P 0. 05）. Meanwhile,Urinary Alb / Cr、NAG、RBP and serum Cys C in group B were significantly higher than those in group A. The combined detection of the four indexes greatly improved detection rate in Group A and B. Conclusion The combined detection of Urinary Alb / Cr、NAG、RBP and serum Cys C is conducive to early diagnosis of diabetes nephropathy and reflection of location.

关 键 词：尿白蛋白 肌酐 尿N-乙酰-β-D氨基葡萄糖 尿视黄醇结合蛋白 血胱抑素C 糖尿病性肾病 

分 类 号：R587.1[医药卫生—内分泌] R446.11[医药卫生—内科学]