90例RhD阴性孕妇血型不合对胎儿和新生儿的影响  

The Adverse Impact of Maternal Blood Incompatibility on Fetuses and Newborn Infants in 90 Cases of Negetive RhD Pregnancies

作　　者：王兰芳[1] 王秀[1] 何刘媛[1] 蔡娟[1] 

机构地区：[1]安徽省妇幼保健院,安徽医科大学附属临床妇幼学院,230001

出　　处：《临床输血与检验》2015年第6期495-498,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨Rh D阴性血型孕妇血型不合及其对胎儿和新生儿的影响。方法对合肥市妇幼保健院2011年1~12月期间产科的90例Rh D阴性孕妇临床资料进行回顾性分析,并抽取同期住院分娩的90例Rh D阳性孕妇作对照。结果 Rh D阴性孕妇早产、新生儿高胆红素血症发生率均高于对照组,差异有统计学意义（P〈0.05）。随产次及抗体效价增加新生儿溶血病发病率增高,差异有统计学意义（P〈0.05）。结论对Rh D阴性妇女孕前应进行宣教,孕后加强管理,尽量减少无效妊娠。孕期应定期监测抗体效价,结合胎儿B超检查可预测新生儿溶血病的发生及严重程度,积极治疗可改善新生儿预后,降低围产儿死亡率。Objective To investigate the impact of the maternal-fetal blood incompability in Rh D-negative pregnancies on the fetuses and newborn infants. Method Ninety cases of Rh D-negative pregnant women were retrospectively analyzed in the obstetrics of Hefei maternal and child care service centre from january 2011 to december 2011. Additionally,90 cases of hospitalized pregnant women with positive Rh D were set up as controls. Results The incidence rate of preterm and neonatal hyperbilirubinemia was found to be higher in Rh D-negative pregnant women than those in control（ P〈0. 05）. The incidence of hemolytic disorders of the newborn babies increased with elevation of parity and antibody titers（ P〈0. 05）. Conclusion Rh D-negative women should be well educated and monitored pre- and post-pregnancy to minimize the resultless pregnancy. Antibody titers should be tested and B ultrasonography is used periodically during pregnancy,which may help make diagnosis and assessment of the severity of neonatal hemolysis,so as to reduce perinatal mortality.

关 键 词：RH阴性血型 抗RhD 新生儿溶血病 

分 类 号：R457.11[医药卫生—治疗学] R556.63[医药卫生—临床医学]