2SZAPXRO治疗小鼠经白消安诱导的再生障碍性贫血模型的效果评价  

Study on the therapeutic effects of 2SZAPXRO on aplastic anemia in a mouse model induced by busulfan

作　　者：易翠林 郝苗 韩丽丽[3] 王玉林[3] 

机构地区：[1]大连活尔生物科技有限公司,辽宁大连116023 [2]大连市食品检验所,辽宁大连116630 [3]大连医科大学基础医学院,辽宁大连116044

出　　处：《辽宁师范大学学报（自然科学版）》2015年第4期522-525,共4页Journal of Liaoning Normal University:Natural Science Edition

摘　　要：2SZAPXRO是一种以海参、牡蛎及枸杞为原料,应用细胞平衡液(BalanCell)技术制备的复合提取液,富含海参黏多糖、海参皂苷、多肽、氨基酸、牛磺酸、多种微量元素和维生素等多种生物活性成分.从中医学角度,该提取液具有补肾益精、滋阴养血的功效.用白消安诱导小鼠,建立再生障碍性贫血动物模型.对再生障碍性贫血小鼠进行口服2SZAPXRO给药治疗,同时设立正常小鼠对照组(未经白消安造模)和无药物治疗组(对白消安造模小鼠不进行2SZAPXRO给药治疗).结果表明:2SZAPXRO复合提取液对小鼠再生障碍性贫血具有显著的治疗效果.2SZAPXRO is an elaborate extraction of sea cucumber,oyster and Chinese wolfberry by the technique of＂BalanCell＂,with various enriched biologically active components,including mucopolysaccharides,polypeptide,amino acid,taurine and diverse trace elements and vitamins.From the view of TCM theory,2SZAPXRO should be of kidney tonifying and blood replenishing.In this study,aplastic anemia was established in mice by administration of busulfan for the in vivo effect evaluation of 2SZAPXRO on aplastic anemia,which was administered to mice orally.Meanwhile,normal control group and non-therapeutic group were set.The results indicated that 2SZAPXRO exhibits excellent in vivo effects on aplastic anemia in a mouse model.

关 键 词：再生障碍性贫血 白消安 小鼠模型 

分 类 号：R979.19[医药卫生—药品]