Endocrine and Metabolic Effects of Hydroethanolic Extract of Solenostemon monostachyus on Haloperidol Induced Hyperprolactinemia  

作　　者：Omoloye Adesina Adebiyi Quasim Kifayat Olabisi Johnson Samuel Onnolome Murtala Abdullahi Akanji 

机构地区：[1]Department of Clinical Pharmacy, Faculty of Pharmacy, Olabisi Onabanjo University Teaching Hospital, Sagamu-Ogun State234, Nigeria [2]Department of Chemical Pathology and Immunology, Olabisi Onabanjo University Teaching Hospital, Sagamu-Ogun State 234,Nigeria [3]Department of Phamacology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu-Ogun State 234, Nigeria

出　　处：《Journal of Pharmacy and Pharmacology》2015年第8期391-399,共9页药剂与药理学（英文版）

摘　　要：The rapid increase in consumption of herbal remedies worldwide has been stimulated by several factors, including the notion that all herbal products are safe and effective. Hyperprolactinemia is a major cause of infertility, and herbal remedies have been employed locally for treatment. This study was designed to investigate the effects of hydroethanolic extract of Solenostemon monostachyus on the reproductive hormones and metabolic parameters of haloperidol-induced hyperprolactinemic rats. Thirty six female albino rats were divided into 6 groups of 6 in each group. Groups A, B, C, D and E were given increasing doses （2, 3 and 4 mg/kg body weight in five-daily increments） of haloperidol by intramuscular injection for 15 days after which they were treated for another 15 days with either 2.5mg/kg body weight ofbromocriptine （group D only） or 75, 112.5 or 225mg/kg body weight of the extract （groups A, B and C, respectively）. Group F was given distilled water only. After treatment, the animals were sacrificed and blood was taken from each group for plasma analysis of the reproductive hormones and metabolic parameters. The total protein and the lipid profile （total cholesterol and HDL （high-density lipoprotein） and triglycerides were also determined. Phytochemical investigation revealed the presence of saponins, phenols, alkaloids, fiavonoids, and tannins. The result of endocrine investigation showed a dose-dependent, statistically significant reduction in prolactin and testosterone （P 〈 0.05） level by the extract with statistical significant increase （P 〈 0.05） in the levels of the follicle stimulating hormone, LH （luteinizing hormone） and estrogen. There was also a decrease in the levels of the triglycerides and total cholesterol while HDL was increased （P 〉 0.05）. It can be concluded from this study, that hydroethanolic extract has a prolactin reducing activity compared with Bromocriptine and exhibited a corresponding statistical significant difference in other reproductive ho

关 键 词：HYPERPROLACTINEMIA BROMOCRIPTINE HALOPERIDOL reproductive hormones Solenostemon monostachyus. 

分 类 号：R9[医药卫生—药学]