Antiasthmatic Effect of Eugenol （4-Allyl-2-Methoxyophenol） Mediated by Both Bronchodilator and Immunomodulatory Properties  

作　　者：Campos Keina Maciele Teixeira Tatiane Oliveira Cerqueira-Lima Ana Tereza Costa Ryan Santos CarneiroTamires Cana Brasil Silva Darizy Faivia Barreto Mauricio Lima Pontes-de-Carvalho Lain Carlos Alcantatara-Neves Neuza Maria Figueiredo Camila Alexandrina 

机构地区：[1]Instituto de CiOncias da Saude, Universidade Federal da Bahia, Salvador, Bahia 41110-100, Brazil [2]lnstituto de Saftde Coletiva, Universidade Federal de Bahia, Rua Basilio da Gama s/n, Canela, Salvador, Bahia 41110-040, Brazil [3]Centro de pesquisa Gongalo Moniz, Fundacao Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2014年第1期38-49,共12页药剂与药理学（英文版）

摘　　要：Eugenol, an aromatic product, exhibits anti-inflammatory properties, however, little is known about its effect in allergic inflammation mediated by Th2-type cells and cytokines. We examined the pharmacological potential of this compound in a murine model of respiratory allergy to Bt （Blomia tropicalis）. For this, AJ mice were sensitized （100μg/animal s.c.） and challenged （10 μg/animal i.n.） with Bt mite extract. Sensitized animals were treated or not with eugenol （20, 40 or 80 mg/kg） and the following parameters were analyzed： number of total cells in BAL （bronchoalveolar lavage）; EPO （eosinophil peroxidase activity） and histopathological changes in the lungs; serum level of specific IgE, IgG1 and IgG2a and; concentration of Th2 cytokines on BAL and spleen cultures. In addition, the capability ofeugenol in relaxing tracheal smooth muscle was also evaluated. Our results showed that treatment with eugenol significantly reduced the airway inflammation, decreasing the cellular infiltrate, EPO and mucus in the lungs, as well as the production of Th2 cytokines. It was also demonstrated a dilator effect of eugenol observed by the relaxation of normal and hyper-reactivity isolated trachea upon carbachol stimulation. These results suggest that eugenol has potential as an anti-asthmatic drug by both bronchodilator and immunomodulatory properties.

关 键 词：ASTHMA BIomia tropicalis  natural products  eugenol. 

分 类 号：R9[医药卫生—药学]