Evaluation of the Antifibrillatory Drug Interactions between Amiodarone and Diltiazem in Isolated Perfused Rabbit Hearts  

作　　者：Abdulrahman Abdullah Almotrefi Mohammad Saad Alhumayyd 

机构地区：[1]Department of Pharmacology, King Saud University, Riyadh 11472, Saudi Arabia

出　　处：《Journal of Pharmacy and Pharmacology》2014年第6期366-370,共5页药剂与药理学（英文版）

摘　　要：The alarming reports of the proarrhythmic effects of several antiarrhythmic agents have stimulated our interest to study the antifibrillatory drug interactions that may occur when antiarrhythmic drugs from different classes are combined. Hearts isolated from New Zealand white rabbits of either sex weighing 1.5 to 2 kg were perfused by the Langendorff method with McEwen＇s solution. We used the serial-shock method of measuring VFT （ventricular fibrillation threshold）, a method that have proved reliable in quantitatively assessing the antifibrillatory potency of many antiarrhythmic drugs we have studied during the last three decades. Perfusion with either amiodarone or diltiazem produced significant, dose-dependent increase in VFT. In addition, there was significant difference in the increase in VFT produced by the combined infusion of 1 μmol of amiodarone and 0.02 μmol of diltiazem and the summation of the increases produced by the separate infusion of these two concentrations. This synergistic antifibrillatory interactions between amiodarone and diltiazem may suggest that catuion has to be taken when amiodarone and diltiazem are combined in the treatment of cardiac arrhythmias as this may lead to a proarrhythmic effect. However, further studies are required to establish this in the clinical setup.

关 键 词：ARRHYTHMIA AMIODARONE deltiazem fibrillation. 

分 类 号：R9[医药卫生—药学]