Controlled Release of Naproxen Sodium from Supermacroporous Cryogels  

作　　者：Ozlem Bicen Unluer Lutfi Genc Sennur Gorgulu Kahyaoglu Arzu Ersoz 

机构地区：[1]Faculty of Science, Anadolu University, Eskisehir 26470, Turkey [2]Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey [3]Plant, Drug and Scientific Research Center (BiBAM), Anadolu University, Eskisehir 26470, Turkey [4]Graduate School of Health, Department of Pharmacology Anadolu University, Eskisehir 26470, Turkey

出　　处：《Journal of Pharmacy and Pharmacology》2014年第9期527-533,共7页药剂与药理学（英文版）

摘　　要：Cryogels are gel matrices that have interconnected macropores and are formed in freezing-thawing systems. These interconnected macropores give elasticity to cryogels. Transdermal controlled-release systems can be used to deliver drugs with short biological half-life and can maintain plasma levels of very potent drugs within a narrow therapeutic range for prolonged periods. In this study, cryogels have been used in a different area--transdermal controlled-release system, to obtain controlled drug release medium. For this purpose, naproxen sodium has been selected as a model drug. Naproxen, a propionic acid derivative, is a NSAID （nonsteroidal anti-inflammatory drug）. For controlled releasing of naproxen sodium, cryogels that have naproxen sodium in macropores have been prepared in sheet form for local application. Acrylamide based cryogel bands have been synthesized by flee radical cryogelation process. These cryogel bands have different pore size and includes naproxen sodium in their pores. This cryogel material has been characterized by swelling tests and SEM. Then, releasing ofnaproxen sodium from cryogels has been investigated at two different pH values, 7.4 and 5.5. According to experimental data, it has seen that these cryogel matrices that including naproxen sodium in macropores could be used in controlled drug releasing systems as bandages or other transdermal controlled releasing agents at room temperature

关 键 词：CRYOGEL macropores controlled release naproxen sodium transdermal releasing agent. 

分 类 号：R9[医药卫生—药学]