促炎性白细胞介素在烧伤炎症反应中的作用  

Roles of proinflammatory interleukin in the inflammatory response after burn injury

作　　者：张庆富[1] 高学坡 

机构地区：[1]河北医科大学第一医院烧伤整形外科,石家庄050031

出　　处：《中华损伤与修复杂志（电子版）》2015年第5期48-51,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：河北省重点基础研究项目(14967724D);河北省自然科学基金(C2011206080);河北省省级重大医学科研课题(zd2013080)

摘　　要：白细胞介素是一类炎症介质,其中促炎性白细胞介素在烧伤全身炎症反应综合征(SIRS)、多器官功能障碍综合征(MODS)、脓毒症、感染性休克发生和发展过程中起重要作用。参与烧伤炎症反应的促炎性白细胞介素主要有白细胞介素1(IL-1)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、白细胞介素18(IL-18)等。本文就上述促炎性白细胞介素在烧伤后炎症反应中作用进行阐述:分别从其生物学功能、烧伤后的变化及作用两方面展开。不同时期采取不同的有效措施减少炎症介质,提高大面积严重烧伤的治疗效果。Interleukin is a class of inflammatory mediators. Proinflammatory interleukin plays an important role in the development of systemic inflammatory response syndrome, multiple organ dysfunction syndrome, sepsis, and septic shock induced by bums. The proinflammatory interleukins involved in the inflammatory response after burn injury include interleukin-1, interleukin-6, interleukin-8, interleukin-18 and so on. This article will review the roles of proinflammatory interleukin in the inflammatory response after burn injury. Taking various effective measures to reduce inflammation medium at different times can improve the therapeutic effect of large area severe burn.

关 键 词：烧伤 白细胞介素类 系统性炎症反应综合征 

分 类 号：R644[医药卫生—外科学]